Abstract: Objective To explore the relationship between negative emotion and the indexes of glucose and lipid metabolism in the elderly patients with type 2 diabetes mellitus (T2DM) complicated with depression. Methods A total of 84 elderly patients with T2DM complicated with depression (study group) and 79 elderly T2DM patients (control group) admitted to the hospital from January 2019 to October 2020 were selected as the research objects. The negative emotion and the glucose and lipid metabolism of the two groups were compared. The correlation between negative emotions and the indicators of glucose and lipid metabolism in the study group was analyzed. Results The scores of the Anxiety Self-Rating Scale (SAS) and the Hamilton Depression Scale (HAMD) in the study group were higher than those in the control group (P<0.05), and the score of Perceived Social Support Scale (PSSS) in the study group was lower than that in the control group (P <0.05). The levels of fasting blood glucose (FPG), glycosylated hemoglobin (HbA1c), insulin resistance index (HOMA-IR), triglycerides (TG) and total cholesterol (TC) in the study group were higher than those in the control group (P＜0.05). The levels of FPG, HbA1c, HOMA-IR, TG and TC in the study group were positively correlated with HAMD score (P<0.05), and were negatively correlated with PSSS score (P<0.05 ). Conclusions Negative emotion is closely related to glucose and lipid metabolism in the elderly patients with T2DM and depression. The more serious the negative emotions, the more disordered the glucose and lipid metabolism. It is recommended to strengthen clinical health education and psycho-emotional treatment.

Key words: type 2 diabetes mellitus, depression, negative emotions, glycolipid metabolism