TRAF3IP2表达水平与老年人群冠脉钙化相关性的临床研究

doi:10.3969/j.issn.1003-9198.2026.06.012

Abstract

Abstract: Objective To investigate the correlation between tumor necrosis factor receptor 3-interacting protein 2 (TRAF3IP2) and coronary artery calcification (CAC) in the elderly population. Methods This was a prospective study. A total of 216 hospitalized patients aged ≥ 60 years who underwent coronary angiography at the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University from October 2024 to August 2025 were selected. According to the presence of coronary artery calcification, the patients were divided into the non-calcification group (n=132) and the calcification group (n=84). The clinical data of the patients were collected, and enzyme-linked immunosorbent assay was used to dectect the serum level of TRAF3IP2. Multivariate logistic regression analysis was used to explore the relationship between TRAF3IP2 and CAC in the elderly population. The predictive efficacy of TRAF3IP2 for CAC was evaluated by receiver operating characteristic (ROC) curve. Results The serum level of TRAF3IP2 in the calcification group was significantly higher than that in the non-calcification group (P<0.05). Logistic regression model showed that TRAF3IP2 was independently and positively correlated with the occurrence and the severity of CAC in the elderly population (after adjustment for all covariates, OR=1.092, 1.166, all P<0.01). ROC curve analysis revealed that the area under the curve (AUC) of TRAF3IP2 for predicting CAC in the elderly population was 0.664, the diagnostic sensitivity was 44.7% and the specificity was 89.3%. Conclusions TRAF3IP2 is correlated with CAC in the elderly population, and it may be involved in the progression of CAC in the elderly population.

Key words: tumor necrosis factor receptor-associated factor 3 interacting protein 2, aged, coronary artery calcification, inflammatory response, biomarker, prospective study

CLC Number:

XU Jie, GENG Jin, ZENG Yang, ZHANG Qing, WANG Bingjian. Clinical study on the correlation between TRAF3IP2 expression level and coronary artery calcification in the elderly[J]. Practical Geriatrics, 2026, 40(6): 602-606.

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Clinical study on the correlation between TRAF3IP2 expression level and coronary artery calcification in the elderly

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