奥赛利定与舒芬太尼静脉自控镇痛对老年胸腔镜肺切除术后疼痛和恢复质量的比较研究

doi:10.3969/j.issn.1003-9198.2026.06.013

Abstract

Abstract: Objective To compare the efficacy of oliceridine and sufentanil for patient-controlled intravenous analgesia (PCIA) in elderly patients after thoracoscopic pulmonary surgery, and to evaluate their impact on postoperative recovery quality. Methods A total of 154 patients scheduled for thoracoscopic lung resection from August to November 2025 were enrolled and randomly assigned to oliceridine group and sufentanil group. After surgery, the oliceridine group received PCIA with oliceridine, while the sufentanil group received PCIA with sufentanil. The analgesic effect within 0-48 h after the loading dose of PCIA was compared between the two groups using the time-weighted sum of pain intensity difference (SPID). The following parameters were recorded: the pressing time of analgesic pump, cases of postoperative rescue analgesia, 15-item Quality of Recovery (QoR-15) scores 24 h and 48 h after operation, time to first ambulation, postoperative hospital stay, and adverse reactions. Results The least squares (LS) mean of SPID during 0-24 h and 24-48 h were significantly lower in the oliceridine group than those in the sufentanil group (P<0.05). The oliceridine group also showed a lower pressing time of analgesic pump and fewer rescue analgesia cases(both P<0.05). Compared with the sufentanil group, the oliceridine group had higher QoR-15 scores 24, 48 h after operation and a shorter time to first ambulation (P<0.05). There was no significant difference in postoperative hospital stay between the two groups (P>0.05). The incidence of postoperative nausea was lower in the oliceridine group (P< 0.05), while no significant differences were observed in postoperative vomiting, constipation, dizziness, pruritus, or severe respiratory depression between the two groups (P>0.05). Conclusions Compared with sufentanil, oliceridine for PCIA after thoracoscopic pulmonary resection in elderly patients provides more effective pain relief, reduces postoperative nausea, and improves the quality of postoperative recovery.

Key words: oliceridine, thoracoscopic pulmonary resection, postoperative analgesia, recovery quality, aged

CLC Number:

R 619

CAI Yongliang, SUN Heliang, JIANG Yihao, WANG Zhongyun. Comparison of patient-controlled intravenous analgesia with oliceridine or sufentanil on postoperative pain and quality of recovery in elderly patients after thoracoscopic pulmonary resection[J]. Practical Geriatrics, 2026, 40(6): 607-612.

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Comparison of patient-controlled intravenous analgesia with oliceridine or sufentanil on postoperative pain and quality of recovery in elderly patients after thoracoscopic pulmonary resection

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