甘油三酯葡萄糖指数、血尿酸/HDL-C比值对老年2型糖尿病肾病的影响及诊断价值研究

doi:10.3969/j.issn.1003-9198.2026.05.009

Abstract

Abstract: Objective To investigate the impact and diagnostic value of triglyceride glucose (TyG) index and serum uric acid (SUA)/high density lipoprotein cholesterol (HDL-C) ratio (UHR) for the occurence of diabetic kidney disease (DKD) in elderly patients with type 2 diabetes mellitus (T2DM). Methods A retrospective analysis was conducted on the clinical data of 251 elderly T2DM patients hospitalized in Department of Endocrinology, Affiliated Hospital of Nanjing University of Chinese Medicine, from February 2023 to October 2025. According to whether they were complicated with DKD, all patients were divided into simple T2DM group (n=150) and combined DKD group (n=101). Baseline characteristics, biochemical parameters, TyG index and UHR were compared between the two groups. Spearman correlation analysis was adopted to assess the relationships among TyG index, UHR and other parameters. Binary logistic regression was applied to identify the risk factors for DKD. Receiver operating characteristic (ROC) curve was drawn to analyze the diagnostic value of TyG index, UHR and combined detection for DKD. Results The levels of TyG index and UHR in the combined DKD group were higher than those in the simple T2DM group (P＜0.05). The TyG index was positively correlated with BMI, HbA1c, FPG, TG, TC, LDL-C, SUA, urinary albumin-to-creatinine ratio(UACR) and UHR, and negatively correlated with HDL-C. UHR was positively correlated with BMI, DM duration, SBP, TG, SUA, Scr, UACR and TyG index, and negatively correlated with TC, HDL-C and eGFR (P＜0.05). Both TyG index and UHR were independent risk factors for the occurrence of DKD (P＜0.05). The areas under the curve for the diagnosis of DKD were 0.765 for TyG index alone, 0.831 for UHR alone, and 0.882 for their combination, respectively. The diagnostic efficacy of the combined detection was superior to that of any single indicator (both P＜0.05). Conclusions The TyG index and UHR are closely related to DKD progression in elderly patients with T2DM. The combined detection of these two indicators demonstrates higher diagnostic efficacy than either indicator alone.

Key words: triglyceride glucose index, serum uric acid/high density lipoprotein cholesterol ratio, aged, type 2 diabetes mellitus, diabetic kidney disease

CLC Number:

LI Shuyi, GUO Jingyi, RUAN Yuan, SUN Xinyi, MIAO Junjun, HUANG Liji, YU Jiangyi, WANG Lijuan. Study on the impact and diagnostic value of triglyceride glucose index and serum uric acid/HDL-C ratio on diabetic kidney disease progression in elderly patients with type 2 diabetes mellitus[J]. Practical Geriatrics, 2026, 40(5): 479-483.

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Study on the impact and diagnostic value of triglyceride glucose index and serum uric acid/HDL-C ratio on diabetic kidney disease progression in elderly patients with type 2 diabetes mellitus

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