中国老年人C反应蛋白-甘油三酯-葡萄糖指数与老年良性前列腺增生患者下尿路症状之间的关系:一项全国纵向队列研究

doi:10.3969/j.issn.1003-9198.2026.04.002

Abstract

Abstract: Objective To investigate the association between C-reactive protein-triglyceride-glucose index (CTI) and the risk of developing lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH/LUTS). Methods This study utilized data from the China Health and Retirement Longitudinal Study (CHARLS) longitudinal cohort from 2011 to 2018, which included 3610 middle-aged and older participants. Multivariable Cox proportional hazards regression models, Kaplan-Meier survival analysis, and restricted cubic splines (RCS) were used to explore the relationship between CTI level and the risk of BPH/LUTS. The predictive performance of CTI was assessed using receiver operating characteristic (ROC) curve analysis. Additionally, subgroup analysis and sensitivity analysis were conducted to evaluate the robustness of the findings. Results During the follow-up period, 630 participants (17.5%) developed BPH/LUTS. After adjusting for potential confounders, each one-unit increase in CTI level was associated with an 8% increased risk of BPH/LUTS (HR=1.08, 95%CI: 1.03-1.25). Compared to the lowest quartile, higher quartiles of CTI were associated with progressively increasing risks of BPH/LUTS (HRs=1.23, 1.29, 1.38, P for trend=0.018). Subgroup analysis indicated that the association between CTI level and BPH/LUTS risk was stronger among participants with a body mass index (BMI) ≥24. RCS analysis further supported an overall linear relationship between CTI level and BPH/LUTS risk. Furthermore, ROC analysis showed that CTI had a stronger predictive performance for BPH/LUTS risk compared to triglyceride-glucose index (TyG) and C-reaction protein alone. Sensitivity analysis confirmed the robustness of these primary findings. Conclusions This study indicates that CTI level are significantly and positively associated with the risk of BPH/LUTS in middle-aged and older men. Moreover, this association varies across different BMI populations. Maintaining lower CTI level may help reduce the risk of BPH/LUTS in middle-aged and older men.

Key words: benign prostatic hyperplasia, lower urinary tract symptoms, C-reactive protein-triglyceride-glucose index, China Health and Retirement Longitudinal Study

CLC Number:

R 691.2

XU Xueyuan, LIU Bohan, FENG Shijian, LUO Deyi. Relationship between C-reactive protein-triglyceride-glucose index and lower urinary tract symptoms due to benign prostatic hyperplasia in Chinese older adults: a nationwide longitudinal cohort study[J]. Practical Geriatrics, 2026, 40(4): 332-339.

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Relationship between C-reactive protein-triglyceride-glucose index and lower urinary tract symptoms due to benign prostatic hyperplasia in Chinese older adults: a nationwide longitudinal cohort study

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