non-HDL-C/HDL-C对老年2型糖尿病患者冠状动脉钙化的预测价值

doi:10.3969/j.issn.1003-9198.2026.01.005

Abstract

Abstract: Objective To explore the predictive value of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) for coronary artery calcification (CAC) in elderly patients with type 2 diabetes mellitus (T2DM). Methods A total of 249 elderly patients with T2DM admitted to Huai’an First People’s Hospital from January to December 2023 were selected. Based on chest CT results, all patients were divided into a non-CAC group and a CAC group using the Shemesh visual calcification score method. NHHR was calculated according to the patients’ laboratory test results. Univariate and multivariate logistic regression analysis were employed to determine whether NHHR was an independent risk factor for CAC in patients with T2DM. Restricted Cubic Spline (RCS) analysis was used to analyze potential nonlinear relationships between NHHR and CAC. The predictive value of NHHR for the presence of CAC was assessed using receiver operating characteristic (ROC) curve analysis. Results Multivariate logistic regression combined with RCS analysis identified both NHHR (OR=1.53, 95%CI: 1.05－2.21) and age (OR=1.07, 95%CI: 1.01－1.13) as independent risk factors for CAC in elderly patients with T2DM (P<0.05), with a linear relationship between NHHR and CAC risk observed. Furthermore, the ROC curve analysis showed that the area under the curve (AUC) for predicting CAC using NHHR was 0.650 (95% CI: 0.563-0.736, P<0.05). At the optimal cut-off value of 2.28, the sensitivity and specificity were 57.0% and 72.0%, respectively. Conclusions An elevated NHHR is associated with an increased risk of CAC in elderly patients with T2DM. NHHR demonstrates a certain predictive value for CAC.

Key words: coronary artery calcification, type 2 diabetes mellitus, non-high-density lipoprotein cholesterol, disorders of lipid metabolism, aged

CLC Number:

R 54

LIU Mengjie, DU Qiuyao, CHEN Xiaoxiao, ZHANG Zequn, ZENG Yang, LEI Shiyu, ZHANG Qing. Predictive value of non-HDL-C/HDL-C for coronary artery calcification in older patients with type 2 diabetes mellitus[J]. Practical Geriatrics, 2026, 40(1): 21-25.

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Predictive value of non-HDL-C/HDL-C for coronary artery calcification in older patients with type 2 diabetes mellitus

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