越鞠丸联合沙库巴曲缬沙坦钠治疗老年心力衰竭合并永久性房颤病人的临床疗效

doi:10.3969/j.issn.1003-9198.2025.10.016

Abstract

Abstract: Objective To investigate the effect of Yueju pill combined with sacubitril/valsartan in the treatment of the elderly patients with permanent atrial fibrillation and heart failure. Methods A total of 100 elderly patients with permanent atrial fibrillation and heart failure admitted to Yixing Hospital of Traditional Chinese Medicine from July 2023 to June 2024 were enrolled and randomly divided into two groups by random number table. The control group was given sacubitril/valsartan combined with ventricular rate control therapy. The study group was given Yueju pill on the basis of control group. The cardiac function and efficacy were compared between the two groups. Results The total effective rate of the study group was 92%, which was higher than that of the control group (74%) (P<0.05). After treatment, the serum levels of intercellular adhesion molecule-1 (ICAM-1), N-terminal pro-brain natriuretic peptide (NT-proBNP) and adrenocorticotropic hormone (ACTH)were significantly lower, and the level of left ventricular ejection fraction (LVEF) was higher in the two groups than those before treatment, especially in the study group, and the differences were statistically significant (P< 0.05). Conclusions Yueju pill combined with sacubitril/valsartan is effective in the treatment of the elderly patients with permanent atrial fibrillation and heart failure,which can effectively improve the cardiac function and improve the quality of life.

Key words: Yueju pill, sacubitril/valsartan, aged, permanent atrial fibrillation, heart failure

CLC Number:

YUAN Tingting, JIANG Jiancong, HUANG Dafeng, LIN Song. Effects of Yueju pill combined with sacubitril/valsartan in the treatment of elderly patients with permanent atrial fibrillation and heart failure[J]. Practical Geriatrics, 2025, 39(10): 1048-1051.

References

[1] 陈孝良, 张银芬, 黄秀峰. 沙库巴曲缬沙坦联合美托洛尔治疗冠心病合并慢性心力衰竭的效果[J]. 临床合理用药, 2024, 17(5): 41-44.
[2] 张舒萌, 常国栋, 康永安. 盐酸阿罗洛尔联合沙库巴曲缬沙坦钠治疗心力衰竭的临床研究[J]. 现代医药卫生, 2024,40(2): 237-240.
[3] 牛洁婷, 王文娟, 赵莉, 等. 沙库巴曲缬沙坦钠治疗急性心肌梗死PCI术后心力衰竭患者的临床研究[J]. 中国临床药理学杂志, 2024, 40(2): 160-164.
[4] 陈慧, 欧阳秋芳, 郭进建, 等. 健心颗粒联合沙库巴曲缬沙坦钠片对心力衰竭大鼠心功能和左室重构的影响[J]. 山西中医, 2024, 40(1): 56-58.
[5] 张瀚文, 于嘉祥, 石岩, 等. 基于肝脏TMT标记定量蛋白质组学技术研究越鞠丸防治“双心疾病”的作用机制[J]. 中国实验方剂学杂志, 2023, 29(1): 26-36.
[6] 许顶立, 宋霖. 《中国心力衰竭诊断和治疗指南2024》解读[J]. 临床心血管病杂志, 2024, 40(6): 437-439.
[7] 高洁, 燕建锋, 方舒, 等. 永久起搏器程控在心房颤动诊断中的临床应用及意义[J]. 现代生物医学进展, 2023,23(6): 1100-1104.
[8] 郑海波. 补阳活血汤联合沙库巴曲缬沙坦钠片治疗阳气亏虚血瘀型慢性心力衰竭急性加重期临床研究[J]. 新中医, 2023, 55(23): 35-40.
[9] 赵佳婧, 陆曙, 彭健. 基于病案分析陆曙教授使用越鞠丸治疗心血管疾病的药物加减及合方规律[J]. 医学信息, 2023, 36(6): 20-24.
[10] 姚渊, 邱复亮, 顾方方. 安定汤加味联合沙库巴曲缬沙坦钠片治疗慢性心力衰竭41例[J]. 中国中医药科技, 2023, 30(6): 1229-1231.
[11] HUANG X M, LI J J, YIN W, et al. Effect of sacubitril valsartan on heart failure with mid-range or preserved ejection fraction in patients on maintenance hemodialysis: real-world experience in a single-center, prospective study[J]. BMC Cardiovasc Disord, 2024, 24(1): 79.
[12] KANG D W, KANG S H, LEE K, et al. Comparative efficacy of vericiguat to sacubitril/valsartan for patients with heart failure reduced ejection fraction: systematic review and network meta-analysis[J]. Int J Cardiol, 2024, 400: 131786.
[13] OLIVEROS E, GRAPSA J. Finding new echocardiographic parameters for reverse cardiac remodeling: isovolumic contraction velocity in heart failure with reduced ejection fraction and effect of sacubitril/valsartan: the PROVE-HF study[J]. J Card Fail, 2024, 30(5): 666-668.
[14] SHULZHENKO L V, PERSHUKOV I V, BATYRALIEV T A, et al. The clinical evolution of diffuse myocardial fibrosis in patients with arterial hypertension and heart failure with mildly reduced ejection fraction treated by olmesartan or sacubitril/valsartan[J]. Kardiologiia, 2023, 63(12): 31-38.

[1]	WANG Meijuan, JIANG Xuezhong, WANG Yi. Advances in the treatment of deep vein thrombosis in the elderly [J]. Practical Geriatrics, 2025, 39(9): 865-870.
[2]	ZHANG Yidan, YANG Jian, LIU Jiao, LI Xia, GONG Li, YAO Jing. Advances in imaging diagnosis of deep vein thrombosis in the elderly [J]. Practical Geriatrics, 2025, 39(9): 871-875.
[3]	DU Haiwen, ZHANG Yidan, LI Xia, LIU Jiao, WEI Shuping. Advances in the epidemiology and risk factors of deep venous thrombosis in the elderly [J]. Practical Geriatrics, 2025, 39(9): 879-882.
[4]	QIAN Jing, YAN Xiaodi, SHEN Chaoyan, YAO Ninghua, SHI Yu, BIAN Yinzhu. Study on the expression of ANLN in tissues of elderly patients with pancreatic cancer and its mechanism of action on pancreatic cancer cells [J]. Practical Geriatrics, 2025, 39(9): 888-893.
[5]	ZHANG Yuwen, CHEN Lijian. Effects of crystalloid preloading and colloid preloading on hemodynamics and early postoperative cognitive function in elderly patients undergoing painless colonoscopy [J]. Practical Geriatrics, 2025, 39(9): 894-898.
[6]	HUANG Yong, WANG Fengfeng, SHI Bosheng, HUANG Li, WANG Zhifei. Transcutaneous acupoint electrical stimulation for postoperative pain management and gastrointestinal function recovery in elderly patients with hip fractures [J]. Practical Geriatrics, 2025, 39(9): 910-914.
[7]	LYU Wenjun, KANG Jing, MO Fei. Study on the current status and influencing factors of activity of daily living in Chinese elderly people from the perspective of health ecology [J]. Practical Geriatrics, 2025, 39(9): 915-919.
[8]	YAN Zhenlong, HUANG Ping, CHEN Meng, TAO Junjie, WANG Yuchuan, CHEN Lili, FAN Ya, LI Zehua, ZHOU Xiaotian. Revision and reliability and validity verification of the Chinese version of Identification of Seniors At Risk in the department of emergency [J]. Practical Geriatrics, 2025, 39(9): 920-923.
[9]	ZHANG Ning, GAO Xiu, KANG Lin, LIU Xiaohong. Analysis of clinical characteristics of 17 elderly patients with pulmonary actinomycosis [J]. Practical Geriatrics, 2025, 39(9): 924-928.
[10]	MO Jun, ZHANG Siping, ZHANG Huanwen, LI Jianjiang, Dannier Abulimiti, HUANG Yifei. Efficacy of selective vertebroplasty in the treatment of multi-segment vertebral osteoporotic fractures [J]. Practical Geriatrics, 2025, 39(9): 929-932.
[11]	YAO Heling, WANG Yu, LI Wansong, LUO Hongjie, LYU Xiaolei,WANG Xin, FENG Lina. Clinical value of white matter hyperintensities for overactive bladder symptom in elderly patients with cerebral small vessel disease [J]. Practical Geriatrics, 2025, 39(9): 933-936.
[12]	YAO Yuan, YANG Yong. Advances in the mechanisms of immunosenescence in elderly patients with non-small cell lung cancer [J]. Practical Geriatrics, 2025, 39(9): 947-951.
[13]	ZHOU Dan, WEI Kexin, DENG Shu, HE Rui. Research progress on the prevention and treatment of venous thromboembolism in elderly using artificial intelligence and wearable devices [J]. Practical Geriatrics, 2025, 39(9): 963-967.
[14]	HE Xinxin, XIE Dongmei, WANG Xiaoling, LI Ying, GAO Langli. Research progress in the application of artificial intelligence in the care for disabled elderly [J]. Practical Geriatrics, 2025, 39(8): 757-761.
[15]	JIANG Huizeng, LIU Jinna, ZHANG Dandan, ZHANG Jie. Advances of the application of artificial intelligence in fall risk management in the elderly [J]. Practical Geriatrics, 2025, 39(8): 762-767.

Effects of Yueju pill combined with sacubitril/valsartan in the treatment of elderly patients with permanent atrial fibrillation and heart failure

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Recommended 10