基于剂量反应分析评估血清同型半胱氨酸水平与老年急性缺血性脑卒中病人失眠的关系

doi:10.3969/j.issn.1003-9198.2025.10.012

Abstract

Abstract: Objective To explore the relationship between serum homocysteine (Hcy) levels and insomnia in the elderly patients with acute ischemic stroke (AIS). Methods A total of 98 elderly patients with AIS in 981st Hospital of China People’s Liberation Army Joint Logistics Support Force from May 2022 to May 2024 were selected and divided into the insomnia group (n=40) and the non-insomnia group (n=58) based on whether insomnia occurred. The clinical data of the two groups were compared, and multiple logistic regression analysis was used to investigate the influencing factors for insomnia in the elderly AIS patients. Restricted cubic spline models were employed to analyze the association between Hcy level and the risk of insomnia in the elderly AIS patients. Results Age, scores of Hamilton Anxiety Scale(HAMA) and Hamilton Depression Scale(HAMD) and serum Hcy level in the insomnia group were higher than those in the non-insomnia group (P<0.05). Multivariate logistic regression analysis showed that age, HAMA score, HAMD score and serum Hcy level were influencing factors for insomnia in the elderly AIS patients (P<0.05). Restricted cubic spline model analysis indicated a nonlinear dose-response relationship between serum Hcy level and the risk of insomnia in the elderly AIS patients (P<0.05). Conclusions There is a nonlinear dose-response relationship between serum Hcy level and the risk of insomnia in the elderly patients with AIS. Monitoring patients’ Hcy levels can help to identify and prevent insomnia early and improve patients’ prognosis.

Key words: acute ischemic stroke, aged, insomnia, homocysteine, dose-response

CLC Number:

R 743.3

LI Lingling, YANG Xiaofeng, JIN Zhao, ZHAO Ning, GUO Xiaoling, ZHANG Nan, SUN Hui. Relationship between serum homocysteine levels and insomnia based on dose-response analysis in elderly patients with acute ischemic stroke[J]. Practical Geriatrics, 2025, 39(10): 1028-1032.

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Relationship between serum homocysteine levels and insomnia based on dose-response analysis in elderly patients with acute ischemic stroke

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