Abstract: Objective To observe the effect of immediate weight-bearing and early ambulation for intertrochanteric fractures after InterTAN nail surgery. Methods From March 2023 to January 2024, a total of 61 patients diagnosed with Jensen type Ⅱ intertrochanteric fractures and postoperative reduction as positive medial cortical support (PMCS) after InterTAN nail surgery were randomly divided into control group (n=31) and experimental group (n=30). The control group was allowed to weight-bearing and ambulation as tolerated 6 weeks after surgery, while the experimental group was allowed to weight-bearing and ambulation within 48 hours after surgery. The length of stay, hospitalization costs, time of clinical fracture healing and the incidence rate of complications 3 months after surgery were recorded. Harris Hip Score(HHS) and Visual Analog Scale (VAS) were evaluated regularly 2 days and 3 months after surgery. Results During the treatment and follow-up stages, 3 patients dropped out from each group, resulting in a final total of 55 patients being included. There was no statistically significant difference in general information such as age, gender and body mass index between the two groups (P>0.05). There were no significant differences in VAS scores between the two groups 2 days and 3 months after surgery (P>0.05). Compared with the control group, the length of stay and time of clinical fracture healing were shorter, and hospitalization costs were lower in the experimental group, with significant differences (P<0.05). There was no statistically significant difference in HHS score between the two groups 2 days after surgery (P>0.05). HHS scores in both groups 3 months after surgery showed significant improvement compared to those 2 days after surgery (P<0.01), especially in the experimental group (P＜0.05). There were no significant differences in the incidence rate of complications between the two groups (17.9% vs 3.7%, χ²=2.833, P=0.092). Conclusions Immediate weight-bearing and early ambulation as tolerated within 48 hours for patients with Jensen type Ⅱ intertrochanteric fractures and postoperative reduction with PMCS after InterTAN nail surgery could shorten the length of stay, reduce hospitalization costs, promote fracture healing and recovery of hip function, without increasing postoperative pain and the failure rate of internal fixation.