不同剂量替格瑞洛在老年急性心肌梗死病人PCI术后抗血小板治疗中的有效性与安全性

doi:10.3969/j.issn.1003-9198.2021.03.009

Abstract

Abstract: Objective To compare the efficacy and safety of antiplatelet therapy in the patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI) between low-dose ticagrelor (180 mg loading, 60 mg twice daily) and standard-dose ticagrelor (180 mg loading, 90 mg twice daily). Methods A total of 196 patients with AMI who were successfully treated by PCI were randomly divided into low-dose ticagrelor group and standard-dose ticagrelor group. The major adverse cardio-cerebrovascular events (MACCE) and bleeding events during hospitalization and one-year follow-up were recorded in detail. Results There was no significant difference in MACCE between low-dose ticagrelor group and standard-dose ticagrelor group during hospitalization (10. 5% vs 11. 7%, P= 0. 825). The risk of minor bleeding (8. 4% vs 18. 6%, P=0. 061) and major bleeding (1. 1% vs 2. 9%, P=0. 622) were comparable between the two groups. Kaplan-Meier survival analysis showed that there was no significant difference in 1-year MACCE-free survival rate between low-dose ticagrelor group and standard-dose ticagrelor group (P=0. 823). The risk of minor bleeding was significantly lower in low-dose ticagrelor group than that in standard-dose ticagrelor group (16. 8% vs 36. 9%, P=0. 002) 1 year after PCI, and there was no significant difference in major bleeding (1. 1% vs 3. 9%, P=0. 371). Conclusions Compared with the routine dose, low-dose ticagrelor does not increase the incidence of MACCE, while reduce the risk of minor bleeding in the patients with AMI after PCI.

Key words: ticagrelor, acute myocardial infarction, percutaneous coronary intervention

CLC Number:

R 543.31

WANG Ning-ning, ZHANG Feng-mei, REN Guo-cheng, WU Di, SONG Shuang, XU Xin-yu. Efficacy and safety of different doses of ticagrelor in elderly patients with acute myocardial infarction after percutaneous coronary intervention[J]. Practical Geriatrics, 2021, 35(3): 246-249.

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Efficacy and safety of different doses of ticagrelor in elderly patients with acute myocardial infarction after percutaneous coronary intervention

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