泛免疫炎症指数与老年糖尿病视网膜病变并黄斑水肿病情严重程度的关系

doi:10.3969/j.issn.1003-9198.2025.04.013

摘要/Abstract

摘要： 目的探讨泛免疫炎症指数(PIV)与老年糖尿病视网膜病变并黄斑水肿病情严重程度的关系。方法选取2021年1月至2024年1月在首都医科大学附属北京康复医院收治的老年糖尿病视网膜病变病人98例,将其中无黄斑水肿的病人作为对照组(n=20),发生黄斑水肿的病人作为观察组(n=78),进一步根据黄斑水肿的严重程度将观察组病人分为轻度组(n=23)、中度组(n=39)和重度组(n=16),比较各组间基线资料的差异,采用logistic回归分析老年糖尿病视网膜病变病人发生黄斑水肿的影响因素。结果观察组与对照组间糖尿病病程及HbA1c、IL-6、PIV水平比较,差异有统计学意义(P<0.01)。Logistic回归分析显示,糖尿病病程、HbA1c、IL-6、PIV均为老年糖尿病视网膜病变病人发生黄斑水肿的独立影响因素(P<0.05)。轻度组、中度组及重度组间PIV、HbA1c、IL-6水平比较,差异均有统计学意义(P<0.05);PIV与HbA1c、IL-6均呈正相关(r=0.611,P<0.01;r=0.653,P<0.01)。结论 PIV与老年糖尿病视网膜病变并发黄斑水肿的严重程度密切相关,可以作为评估老年糖尿病并发黄斑水肿病情严重程度的重要指标,为临床诊断和治疗提供参考依据。

关键词: 糖尿病视网膜病变, 泛免疫炎症指数, 黄斑水肿, 老年人

Abstract: Objective To explore the relationship between pan-immune-inflammation index (PIV) and the severity of macular edema in the elderly with diabetic retinopathy. Methods A total of 98 elderly patients with diabetic retinopathy admitted to Beijing Rehabilitation Hospital Affiliated to Capital Medical University from January 2021 to January 2024 were enrolled in this study. The patients without macular oedema were enrolled in the control group (n=20), and the patients with macular edema were enrolled in the observation group (n=78). According to the severity of macular edema, the patients in the observation group were divided into mild group (n=23), moderate group (n=39) and severe group (n=16). The baseline data were compared among the groups. Logistic regression analysis was used to analyze the influencing factors of macular edema in the elderly patients with diabetic retinopathy. Results There were significant differences in the duration of diabetes, the levels of hemoglobin A1c (HbA1c), interleukin-6 (IL-6) and PIV between the observation group and the control group (P<0.01). Logistic regression analysis showed that the duration of diabetes, the levels of HbA1c, IL-6 and PIV were independent influencing factors for macular edema in the elderly patients with diabetic retinopathy (P<0.05). There were significant differences in the levels of PIV, HbA1c and IL-6 among mild group, moderate group and severe group (P<0.05). PIV was positively correlated with the levels of HbA1c and IL-6 (r=0.611, P<0.01; r=0.653, P<0.01). Conclusions PIV is closely related to the severity of macular edema in the elderly patients with diabetic retinopathy, which can be used as an important indicator to evaluate the severity of macular edema in the elderly patients with diabetic retinopathy, and to provide reference for clinical diagnosis and treatment.

Key words: diabetic retinopathy, pan-immune-inflammation index, macular edema, aged

中图分类号:

安方杰, 刘莹, 赵贺. 泛免疫炎症指数与老年糖尿病视网膜病变并黄斑水肿病情严重程度的关系[J]. 实用老年医学, 2025, 39(4): 387-390.

AN Fangjie, LIU Ying, ZHAO He. Relationship between pan-immune-inflammation index and the severity of diabetic retinopathy with macular edema in elderly patients[J]. Practical Geriatrics, 2025, 39(4): 387-390.

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