超高龄慢性肾脏病病人标化尿酸与肾功能的相关性研究

doi:10.3969/j.issn.1003-9198.2024.08.006

摘要/Abstract

摘要： 目的探讨超高龄慢性肾脏病病人标化尿酸与肾功能的相关性,为超高龄晚期慢性肾脏病病人降尿酸药物治疗提供参考。方法回顾性收集在滁州市第一人民医院年龄≥90岁的出院病人临床资料,包括基本情况、肾功能指标、用药情况等,分析标化尿酸(血尿酸/血肌酐比值)和各肾功能指标的相关性。结果共纳入58例超高龄老年慢性肾脏病病人82例次病历资料,病人入院时和出院前的血尿酸和肾功能指标无明显变化,使用降尿酸药物后尿酸和其他肾功能指标差异均无统计学意义(P>0.05)。标化尿酸与血肌酐(r=-0.678)、尿素氮(r=-0.505)、胱抑素C(r=-0.611)呈负相关,与肾小球滤过率呈正相关(r=0.738,P＜0.01)。结论超高龄慢性肾脏病病人标化尿酸与肾功能指标相关性强,降尿酸药物使用不能明显改善超高龄慢性肾脏病病人的肾功能,相反标化尿酸在一定范围内升高可能有助于肾功能指标的改善。

关键词: 超高龄, 肾脏病, 标化尿酸, 肾功能, 相关性

Abstract: Objective To explore the correlation between standardized uric acid[serum uric acid (SUA) /serum creatinine(Scr)] and renal function in the elderly patients with chronic kidney disease(CKD) aged ≥90 years old, and to provide reference for the treatment of SUA. Methods The clinical data of the elderly patients with CKD aged ≥ 90 years old at First People’s Hospital of Chuzhou were retrospectively analyzed, including basic information, renal function indicators, medication use. The correlation of SUA and standardized uric acid with renal function indicators were analyzed. Results A total of 82 medical records of 58 patients were enrolled, and there was no significant change in renal function during hospitalization. The levels of SUA and renal function indicators after using uric acid lowering drugs showed no significant differences with those before treatment(P>0.05). Standardized uric acid was negatively correlated with Scr (r=-0.678), urea nitrogen (r=-0.505) and cystatin C (r=-0.611), while positively correlated with estimated glomerular filtration rate(eGFR) (r=0.738, P＜0.01). Conclusions Standardized uric acid has a strong correlation with renal function indicators in the elderly patients with CKD aged ≥ 90 years old. The use of uric acid lowering drugs cannot significantly improve renal function. On the contrary, an increase in standardized uric acid within a certain range may help improve the renal function indicators in these patients.

Key words: aged ≥ 90 years, kidney disease, standardized uric acid, renal function, correlation

中图分类号:

R692

沈陈军, 王小庆, 汤德刚, 宁萍. 超高龄慢性肾脏病病人标化尿酸与肾功能的相关性研究[J]. 实用老年医学, 2024, 38(8): 779-782.

SHEN Chenjun, WANG Xiaoqing, TANG Degang, NING Ping. Correlation between standardized uric acid and renal function in elderly patients with chronic kidney disease aged 90 and over[J]. Practical Geriatrics, 2024, 38(8): 779-782.

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