老年大疱性类天疱疮住院病人衰弱现状及影响因素分析

doi:10.3969/j.issn.1003-9198.2023.07.016

摘要/Abstract

摘要： 目的调查老年大疱性类天疱疮(BP)住院病人的衰弱现状及其影响因素。方法采用便利抽样法,选取2020年8月至2022年2月在四川大学华西医院皮肤性病科住院的104例老年BP病人。使用FRAIL衰弱量表、Barthel指数、营养风险筛查2002量表(NRS2002)、匹兹堡睡眠质量指数量表(PSQI)分别评估病人的衰弱情况、日常生活活动能力(ADL)、营养风险及睡眠质量,同时收集病人的一般资料、疾病相关资料及实验室检查结果,采用Logistic回归分析老年BP住院病人衰弱的影响因素。结果老年BP住院病人处于非衰弱/衰弱前期40例(38.5%),衰弱期64例(61.5%)。单因素分析结果显示,非衰弱/衰弱前期组和衰弱组之间年龄、BMI、合并症数量、卧床、脑卒中史、冠心病、慢性肺部疾病、下肢静脉血栓、使用激素治疗、抗BP-180抗体、ADL、NRS2002、血红蛋白、血清白蛋白、CRP、BNP、HbA1c、TC、钙离子水平差异均有统计学意义。Logistic回归分析结果显示,年龄(OR=1.248,95%CI:1.073～1.450)、ADL(OR=0.966,95%CI:0.939～0.993)、抗BP-180抗体(OR=1.035,95%CI:1.018～1.052)、CRP(OR=1.027,95%CI:1.005～1.048)、BNP(OR=1.004,95%CI:1.001～1.007)是老年BP病人衰弱的影响因素。结论老年BP住院病人衰弱发生率高。高龄、自理能力下降、抗BP-180抗体升高、CRP升高和BNP升高的老年BP住院病人更易出现衰弱。

关键词: 大疱性类天疱疮, 老年人, 衰弱, 影响因素

Abstract: Objective To investigate the frailty status and influencing factors in the elderly inpatients with bullous pemphigoid(BP). Methods A total of 104 elderly inpatients with BP in Department of Dermatology and Venereology, West China Hospital of Sichuan University from August 2020 to February 2022 were selected by convenience sampling method. FRAIL Scale, Barthel Index, Nutrition Risk Screening 2002(NRS2002), and Pittsburgh Sleep Quality Index Scale(PSQI) were applied to evaluate the frailty condition, activities of daily living(ADL), nutritional risks and sleep quality of the elderly hospitalized patients with BP, and the general data, disease-related data and laboratory examination results were collected. Logistic regression was used to analyze the influencing factors of frailty. Results Among the elderly hospitalized patients with BP, 64 cases(61.5%) presented with frailty. Univariate analysis showed that the differences in age, body mass indes(BMI), comorbidities, bed rest, stroke history, coronary heart disease, chronic lung disease, lower limb venous thrombosis, hormonal therapy, the levels of anti-BP-180 antibody, ADL, NRS2002, hemoglobin, serum albumin, C-reactive protein(CRP),brain natriuretic peptide(BNP),glycosylated hemoglobin(HbA1c), total cholesterol and calcium ion between non-frailty/pre-frailty group and frailty group were statistically significant(P<0.05 or P<0.01). Logistic regression analysis showed that age(OR=1.248,95%CI:1.073-1.450)), ADL(OR=0.966,95%CI:0.939-0.993), anti-BP-180 antibody(OR=1.035,95%CI:1.018-1.052), CRP (OR=1.027,95%CI:1.005-1.048), BNP(OR=1.004,95%CI:1.001-1.007)were the influencing factors of frailty in the elderly patients with BP. Conclusions The incidence rate of frailty in the elderly hospitalized patients with BP is high. The elderly hospitalized patients with BP who are older, have decreased self-care ability, elevated anti-BP-180 antibody, elevated CRP and elevated BNP are more prone to presenting with frailty.

Key words: bullous pemphigoid, aged, frailty, influencing factor

中图分类号:

R 758.66

苟辉, 项红梅, 邹琴, 陈吉辉. 老年大疱性类天疱疮住院病人衰弱现状及影响因素分析[J]. 实用老年医学, 2023, 37(7): 714-718.

GOU Hui, XIANG Hong-mei, ZOU Qin, CHEN Ji-hui. Analysis of the frailty status and influencing factors in elderly inpatients with bullous pemphigoid[J]. Practical Geriatrics, 2023, 37(7): 714-718.

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