实用老年医学

实用老年医学 ›› 2022, Vol. 36 ›› Issue (2): 173-176.doi: 10.3969/j.issn.1003-9198.2022.02.016

• 临床研究 • 上一篇    下一篇

老年与中青年病人应用利奈唑胺致血小板减少的比较

刘洋, 何玮, 梁培, 许莹, 曲晨, 顾勤, 董丹江   

  1. 210008 江苏省南京市,南京大学医学院附属鼓楼医院重症医学科(刘洋,许莹,顾勤,董丹江);药学部(梁培);
    210011 江苏省南京市,南京医科大学第二附属医院老年医学科(何玮,曲晨)
  • 收稿日期:2021-03-26 出版日期:2022-02-20 发布日期:2022-02-28
  • 通讯作者: 董丹江,Email:dongdanjiang@sina.com
  • 基金资助:
    江苏省南京药学会科研基金项目(2019YX018)

Comparison of linezolid induced thrombocytopenia in elderly and young patients

LIU Yang, HE Wei, LIANG Pei, XU Ying, QU Chen, GU Qin, DONG Dan-jiang   

  1. LIU Yang, XU Ying, GU Qin, DONG Dan-jiang. Intensive Care Unit; LIANG Pei.Medicine Department, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China;
    HE Wei, QU Chen. Department of Geriatrics, the Second Hospital Affiliated to Nanjing Medical University, Nanjing 210011, China
  • Received:2021-03-26 Online:2022-02-20 Published:2022-02-28

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摘要： 目的 比较老年与中青年病人应用利奈唑胺治疗致PLT减少的发生情况,并分析相关危险因素。方法 回顾性分析南京大学医学院附属鼓楼医院2018年1月至2019年12月90例接受静脉注射利奈唑胺病人的临床资料,根据年龄分为老年组(≥60岁)45例、中青年组(18～59岁)45例,比较2组基线水平,以是否发生PLT减少为因变量,将基线水平差异有统计学意义的因素作为自变量纳入二元Logistic回归模型,分析药物相关PLT减少的危险因素。 结果 老年组高血压患病率、糖尿病患病率、初始PLT计数高于中青年组,胆红素、肌酐清除率低于中青年组,差异均有统计学意义(均P＜0.05)。Logistic回归模型显示,年龄是PLT减少的重要预测因素(P＜0.05)。 结论 老年病人使用利奈唑胺时应密切监测PLT计数。

关键词: 利奈唑胺, 血小板减少, 老年人

Abstract: Objective To compare the incidence of linezolid-related thrombocytopenia between the elderly and non-elderly patients, and to analyze the risk factors of drug-related thrombocytopenia. Methods Retrospective analysis was performed on 90 adult patients treated with intravenous injection of linezolid. All the patients were divided into young and middle-aged group and elderly group. The risk factors for linzolid-related thrombocytopenia were explored by multiple Logistic regression model. Results In the elderly group, the prevalence of hypertension, diabetes mellitus and initial platelet count were significantly higher, while the levels of bilirubin and creatinine clearance rate were significantly lower than those in the young and middle-aged group(all P<0.05). In the Logistic regression model, after adjusting multiple baseline risk factors according to pre-determined criteria, the age was the most important predictor of thrombocytopenia(P<0.05). Conclusions PLT count should be closely monitored when linezolid is used in the elderly patients.

Key words: linezolid, thrombocytopenia, aged

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