不同营养状态老年慢性心力衰竭病人血清IGF-1及IL-17的表达及其影响因素

doi:10.3969/j.issn.1003-9198.2022.01.019

摘要/Abstract

摘要： 目的研究不同营养状态老年慢性心力衰竭(CHF)病人血清胰岛素样生长因子1(IGF-1)及IL-17的表达及其影响因素。方法选取200例2016年12月至2018年12月我院收治的60岁以上的老年CHF病人,根据微型营养评估量表(MNA)评分将病人分为有营养不良风险及营养不良(营养不良)组(MNA<24分)和营养正常组(MNA≥24分)。测量病人身高和体质量并计算病人BMI,测量臂围(AMC)、小腿围(CC)、三头肌皮褶厚度(TSF);测定病人血清中总蛋白(TP)、转铁蛋白(TRF)、前白蛋白(PA)、TC、TG和Hb水平。采用多元线性回归分析IGF-1、IL-17与病人状态的关系。结果营养正常组IGF-1水平显著高于营养不良组,IL-17水平显著低于营养不良组(P<0.05);营养正常组BMI、AMC、CC和TSF水平及TP、TRF、PA、TC、TG和Hb水平均显著高于营养不良组(P<0.05);病人BMI、AMC、CC、TSF、TP、PA、Hb与IGF-1水平呈正相关,与IL-17水平呈负相关,是IGF-1和IL-17水平的独立影响因素。结论在老年CHF病人中,IGF-1和IL-17水平与营养状态关系密切,营养不良影响老年CHF病人预后。

关键词: 慢性心力衰竭, 老年人, 白细胞介素-17, 胰岛素样生长因子-1, 微型营养评估

Abstract: Objective To study the expression of serum insulin like growth factor 1(IGF-1) and interleukin 17 (IL-17) and the influencing factors in the elderly patients with chronic heart failure (CHF) with different nutritional status. Methods A total of 200 elderly patients with CHF aged over 60 years old who were admitted to our hospital from December 2016 to December 2018 were selected as the subjects. According to the scores of the Mini Nutritional Assesment Scale (MNA), the patients were divided into malnutrition group (MNA<24) and normal nutrition group (MNA≥24). The levels of body mass index (BMI), upper arm circumference (AMC), calf circumference (CC), triceps skinfold thickness (TSF) were measured and compared between the two groups; The serum levels of total protein (TP), transferrin (TRF), prealbumin (PA), total cholesterol (TC), triacylglycerol (TG), hemoglobin (Hb), IGF-1 and IL-17 were detected and compared between the two groups. The linear regression model was established by stepwise regression to analyze the relationship between plasma IGF-1, LI-17 and nutritional status. Results The level of IGF-1 in the normal nutrition group was significantly higher, and the level of IL-17 was significantly lower than that in the malnutrition group (P<0.05); The levels of BMI, AMC, CC and TSF in the normal nutrition group were significantly higher than those in the malnutrition group (P<0.05). The levels of TP, TRF, PA, TC, TG and Hb in the normal nutrition group were significantly higher than those in the malnutrition group (P<0.05); The levels of BMI, AMC, CC, TSF, TP, PA, Hb were positively correlated with the level of IGF-1, and negatively correlated with the level of IL-17. They were the independent influencing factors of IGF-1 and IL-17. Conclusions In the elderly patients with CHF, the levels of IGF-1 and IL-17 are closely related to nutritional status. Malnutrition is a risk factor for the prognosis of the elderly patients with CHF.

Key words: chronic heart failure, aged, interleukin-17, insulin-like factor-1, mini nutritional assessment

中图分类号:

R 541

李伟, 赵翠, 王国玉, 蒋海森. 不同营养状态老年慢性心力衰竭病人血清IGF-1及IL-17的表达及其影响因素[J]. 实用老年医学, 2022, 36(1): 73-76.

LI Wei, ZHAO Cui, WANG Guo-yu, JIANG Hai-sen. The expression and influencing factors of serum IGF-1 and IL-17 in elderly patients with chronic heart failure with different nutritional status[J]. Practical Geriatrics, 2022, 36(1): 73-76.

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