实用老年医学

实用老年医学 ›› 2025, Vol. 39 ›› Issue (11): 1109-1112.doi: 10.3969/j.issn.1003-9198.2025.11.007

• 临床研究 • 上一篇    下一篇

老年重症社区获得性肺炎病人前白蛋白变化类型与28d预后的相关性

张剑, 崔晶, 李全瑞, 田耕   

  1. 100053 北京市,首都医科大学宣武医院感染性疾病科
  • 收稿日期:2025-03-18 发布日期:2025-11-26
  • 通讯作者: 田耕,Email:geng_tian@xwhosp.org

Correlation of prealbumin change patterns with 28-day prognosis in elderly patients with severe community-acquired pneumonia

ZHANG Jian, CUI Jing, LI Quanrui, TIAN Geng   

  1. Department of Infectious Diseases, Xuanwu Hospital Capital Medical University, Beijing 100053, China
  • Received:2025-03-18 Published:2025-11-26
  • Contact: TIAN Geng, Email: geng_tian@xwhosp.org

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摘要： 目的 探索前白蛋白(PA)动态变化类型与老年重症社区获得性肺炎(SCAP)病人28 d预后的相关性。方法 纳入2024年1月至2025年1月首都医科大学宣武医院收入院的老年SCAP病人80例,根据28 d预后分为生存组和死亡组,比较2组病人入院第1、4、7天PA水平差异;根据PA变化类型分为先升后降组、持续降低组以及其他类型组,比较3组生存曲线。结果 入院第1天、第4天,生存组与死亡组PA水平差异无统计学意义(P＞0.05),入院第7天,生存组PA水平为(140.0±59.1)mg/L,显著高于死亡组的(107.9±51.6)mg/L(P<0.05)。2组PA变化类型分布差异有统计学意义(P<0.05)。PA先升后降组中位生存时间为19.0(12.3,26.3)d,持续降低组为8.5(3.5,12.3)d,其他类型组为28 d,3组病人生存曲线差异具有统计学意义(P<0.001)。结论 PA动态变化类型与老年SCAP病人28 d病死率相关。

关键词: 老年人, 重症社区获得性肺炎, 前白蛋白, 预后

Abstract: Objective To explore the correlation between dynamic change pattern of prealbumin (PA) and 28-day prognosis in elderly patients with severe community-acquired pneumonia (SCAP). Methods A total of 80 elderly patients with SCAP admitted to Xuanwu Hospital Capital Medical University from January 2024 to January 2025 were enrolled. The patients were divided into survival group and death group based on 28-day outcomes. The level of PA on the first day, fourth day and seventh day of admission were compared between the two groups. According to the type of PA change, the patients were divided into the group with initial rise and then decline, the group with continuous decrease and the group with other types, and the survival curves of the three groups were compared. Results On the first and fourth day of hospitalization, there was no statistically significant differenct in PA levels betwwen the survial group and death group (P＞0.05); On the seventh day, the level of PA in the survival group (140.0±59.1 mg/L) was significantly higher than that in the death group (107.9±51.6 mg/L) (P<0.05). There was a significant difference in the distribution of PA change patterns between the two groups (P<0.05). Median survival time was highest in the group with other types, followed by the group with initial rise and then decline and the group with continuous decrease (P<0.001). Conclusions Dynamic PA change patterns is associated with 28-day mortality in the elderly patients with SCAP.

Key words: aged, severe community-acquired pneumonia, prealbumin, prognosis

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