[1] CUI X, WANG S, CAO H, et al. A review: the bioactivities and pharmacological applications of Polygonatum sibiricum polysaccharides[J]. Molecules, 2018, 23(5):1170. [2] LIU N, DONG Z, ZHU X, et al. Characterization and protective effect of Polygonatum sibiricum polysaccharide against cyclophosphamide-induced immunosuppression in Balb/c mice[J]. Int J Biol Macromol, 2018, 107(Pt A): 796-802. [3] YELITHAO K, SURAYOT U, LEE J H, et al. RAW264.7 cell activating glucomannans extracted from rhizome of Polygonatum sibiricum[J]. Prev Nutr Food Sci, 2016, 21(3):245-254. [4] YANG J X, WU S, HUANG X L, et al. Hypolipidemic activity and antiatherosclerotic effect of polysaccharide of Polygonatum sibiricum in rabbit model and related cellular mechanisms[J]. Evid Based Complement Alternat Med, 2015, 2015:391065. [5] SU L L, LI X, GUO Z J, et al. Effects of different steaming times on the composition, structure and immune activity of Polygonatum polysaccharide[J]. J Ethnopharmacol, 2023, 310:116351. [6] WANG S, WANG B, HUA W, et al. De novo assembly and analysis of Polygonatum sibiricum transcriptome and identification of genes involved in polysaccharide biosynthesis[J]. Int J Mol Sci, 2017, 18(9):1950. [7] CHEN S C, YANG C S, CHEN J J. Main bioactive components and their biological activities from natural and processed rhizomes of polygonum sibiricum[J]. Antioxidants: Basel, 2022, 11(7):1383. [8] ZHU X, LI Q, LU F, et al. Antiatherosclerotic potential of rhizoma polygonati polysaccharide in hyperlipidemia-induced atherosclerotic hamsters[J]. Drug Res: Stuttg, 2015, 65(9):479-483. [9] XU Q, XU J, ZHANG K, et al. Study on the protective effect and mechanism of Dicliptera chinensis (L.) Juss (Acanthaceae) polysaccharide on immune liver injury induced by LPS[J]. Biomed Pharmacother, 2021, 134:111159. [10]LINTON P J, DORSHKIND K. Age-related changes in lymphocyte development and function[J]. Nat Immunol, 2004, 5(2):133-139. [11]MÜLLER L, DI BENEDETTO S, PAWELEC G. The immune system and its dysregulation with aging[J]. Subcell Biochem, 2019, 91:21-43. [12]HE Y, HUANG L, JIANG P, et al. Immunological regulation of the active fraction from Polygonatum sibiricum F. Delaroche based on improvement of intestinal microflora and activation of RAW264.7 cells[J]. J Ethnopharmacol, 2022, 293:115240. [13]ZHAO H, WANG Q L, HOU S B, et al. Chemical constituents from the rhizomes of Polygonatum sibiricum Red. and anti-inflammatory activity in RAW264.7 macrophage cells[J]. Nat Prod Res, 2019, 33(16):2359-2362. [14]ZHU S, LIU P, WU W, et al. Multi-constituents variation in medicinal crops processing: investigation of nine cycles of steam-sun drying as the processing method for the rhizome of Polygonatum cyrtonema[J]. J Pharm Biomed Anal, 2022, 209:114497. [15]LIU D, TANG W, HAN C, et al. Advances in Polygonatum sibiricum polysaccharides: extraction, purification, structure, biosynthesis, and bioactivity[J]. Front Nutr, 2022, 9:1074671. [16]SHEN W D, LI X Y, DENG Y Y, et al. Polygonatum cyrtonema Hua polysaccharide exhibits anti-fatigue activity via regulating osteocalcin signaling[J]. Int J Biol Macromol, 2021, 175:235-241. [17]YELITHAO K, SURAYOT U, PARK W, et al. Effect of sulfation and partial hydrolysis of polysaccharides from Polygonatum sibiricum on immune-enhancement[J]. Int J Biol Macromol, 2019, 122:10-18. [18]CHEN W, CHENG H, XIA W. Construction of Polygonatum sibiricum polysaccharide functionalized selenium nanoparticles for the enhancement of stability and antioxidant activity[J]. Antioxidants: Basel, 2022, 11(2):240. [19]WANG Y, LIU N, XUE X, et al. Purification, structural characterization and in vivo immunoregulatory activity of a novel polysaccharide from Polygonatum sibiricum[J]. Int J Biol Macromol, 2020, 160:688-694. [20]MCHUGH D, GIL J. Senescence and aging: causes, consequences, and therapeutic avenues[J]. J Cell Biol, 2018, 217(1):65-77. [21]SCHMEER C, KRETZ A, WENGERODT D, et al. Dissecting aging and senescence-current concepts and open lessons[J]. Cells, 2019, 8(11):1146. [22]LI B, WU P, FU W, et al. The role and mechanism of miRNA-1224 in the Polygonatum sibiricum polysaccharide regulation of bone marrow-derived macrophages to osteoclast differentiation[J]. Rejuvenation Res, 2019, 22(5):420-430. [23]ZENG G F, ZHANG Z Y, LU L, et al. Protective effects of Polygonatum sibiricum polysaccharide on ovariectomy-induced bone loss in rats[J]. J Ethnopharmacol, 2011, 136(1):224-229. [24]PENG X, HE J, ZHAO J,et al. Polygonatum sibiricum polysaccharide promotes osteoblastic differentiation through the ERK/GSK-3β/β-catenin signaling pathway in vitro[J]. Rejuvenation Res, 2018, 21(1):44-52. [25]DU L, NONG M N, ZHAO J M, et al. Polygonatum sibiricum polysaccharide inhibits osteoporosis by promoting osteoblast formation and blocking osteoclastogenesis through Wnt/β-catenin signalling pathway[J]. Sci Rep, 2016, 6:32261. [26]ZHANG Z, YANG B, HUANG J, et al. Identification of the protective effect of Polygonatum sibiricum polysaccharide on d-galactose-induced brain ageing in mice by the systematic characterization of a circular RNA-associated ceRNA network[J]. Pharm Biol, 2021, 59(1):347-366. [27]MA W, WEI S, PENG W,et al. Antioxidant effect of Polygonatum sibiricum Polysaccharides in D-galactose-induced heart aging mice[J]. Biomed Res Int, 2021, 2021:6688855. [28]TANG X Y, XIE J, QIN Y, et al. Proteomic analysis reveals that Polygonatum cyrtonema Hua polysaccharide ameliorates mice muscle atrophy in chemotherapy-induced cachexia[J]. J Pharm Biomed Anal, 2023, 234: 115533. [29]ZHENG S. Protective effect of Polygonatum sibiricum Polysaccharide on D-galactose-induced aging rats model[J]. Sci Rep, 2020, 10(1):2246. [30]LI J, WANG X, ZHOU R,et al. Polygonatum cyrtonema Hua Polysaccharides Protect BV2 microglia relief oxidative stress and ferroptosis by regulating NRF2/HO-1 pathway[J]. Molecules, 2022, 27(20):7088. |