中药灵芝多糖抗衰老作用的研究进展

doi:10.3969/j.issn.1003-9198.2024.04.002

摘要/Abstract

摘要： 人类衰老是不可避免的自然过程,其过程与器官功能逐渐丧失和再生能力下降相关。中医药在抗衰老领域具有悠久的历史,其理论独特,优势显著,是抗衰老研究的热点。灵芝作为常用的抗衰老中药,具有多种保健和药用功效。灵芝多糖是发挥灵芝大部分抗衰老治疗功能和性能的最具生物活性的成分。本综述回顾了灵芝多糖在抗衰老研究领域的进展以及其抗衰老的具体机制,以充分发挥其天然优势和独特价值,为中药抗衰老的研发和合理应用提供科学依据和重要参考。

关键词: 中药, 灵芝多糖, 抗衰老, 机制

中图分类号:

R 285.6

李铭麟, 王佳贺. 中药灵芝多糖抗衰老作用的研究进展[J]. 实用老年医学, 2024, 38(4): 330-333.

参考文献

[1] 林德颖, 蔡时青. 衰老机制和衰老干预研究的近期进展和前景展望[J]. 中国医学前沿杂志:电子版, 2023, 15(10): 26-27.
[2] MYLONAS A, O'LOGHLEN A. Cellular senescence and ageing: mechanisms and interventions[J]. Front Aging, 2022, 3: 866718.
[3] 李海英, 王亮, 朱凌凌. 中医学视野下女子抗衰老理论研究[J]. 中华中医药杂志, 2020, 35(10): 4907-4910.
[4] 孙晓康, 张艳艳, 张晓元, 等. 衰老机制及抗衰老治疗的研究进展[J]. 食品与药品, 2022, 24(1): 74-80.
[5] 郑心怡, 马国. 抗衰老中药的研究进展[J]. 药学研究, 2021, 40(6): 386-391.
[6] 王静静. 灵芝多糖对小鼠巨噬细胞免疫功能的影响研究[J]. 中国医药指南, 2012, 10(21): 471-472.
[7] BABY S, JOHNSON A J, GOVINDAN B. Secondary metabolites from Ganoderma[J]. Phytochemistry, 2015, 114: 66-101.
[8] WANG J, CAO B, ZHAO H, et al. Emerging roles of Ganoderma lucidum in anti-aging[J]. Aging Dis, 2017, 8(6): 691-707.
[9] NIE S, ZHANG H, LI W, et al. Current development of polysaccharides from Ganoderma: isolation, structure and bioactivities[J]. Bioact Carbohydr Diet Fibre, 2013, 1(1): 10-20.
[10]王颖, 魏佳韵, 吴思佳, 等. 灵芝多糖结构特征及药理作用的研究进展[J]. 中成药, 2019, 41(3): 627-635.
[11]CÖR ANDREJČ D, KNEZ Ž, KNEZ MAREVCI M. Antioxidant, antibacterial, antitumor, antifungal, antiviral, anti-inflammatory, and nevro-protective activity of Ganoderma lucidum: an overview[J]. Front Pharmacol, 2022, 13: 934982.
[12]LUO H, TAN D, PENG B, et al. The pharmacological rationales and molecular mechanisms of Ganoderma lucidum polysaccharides for the therapeutic applications of multiple diseases[J]. Am J Chin Med, 2022, 50(1): 53-90.
[13]KAYALI R, CAKATAY U, AKÇAY T, et al. Effect of alpha-lipoic acid supplementation on markers of protein oxidation in post-mitotic tissues of ageing rat[J]. Cell Biochem Funct, 2006, 24(1): 79-85.
[14]MUSCARI C, GIACCARI A, GIORDANO E, et al. Role of reactive oxygen species in cardiovascular aging[J]. Mol Cell Biochem, 1996, 160-161, 159-166.
[15]TRUSHINA E, MCMURRAY C T. Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases[J]. Neuroscience, 2007, 145(4): 1233-1248.
[16]SHI X, CHENG W, WANG Q, et al. Exploring the protective and reparative mechanisms of G. lucidum polysaccharides against H(2)O(2)-induced oxidative stress in human skin fibroblasts[J]. Clin Cosmet Investig Dermatol, 2021, 14: 1481-1496.
[17]WIHASTUTI T A, AMIRUDDIN R, CESA F Y, et al. Decreasing angiogenesis vasa vasorum through Lp-PLA2 and H2O2 inhibition by PSP from Ganoderma lucidum in atherosclerosis: in vivo diabetes mellitus type 2[J]. J Basic Clin Physiol Pharmacol, 2020, 30(6):/j/jbcpp.2019.30.issue-6/jbcpp-2019-0349/jbcpp-2019-0349.xml.
[18]LI H N, ZHAO L L, ZHOU D Y, et al. Ganoderma lucidum polysaccharides ameliorates hepatic steatosis and oxidative stress in db/db mice via targeting nuclear factor E2 (erythroid-derived 2)-related factor-2/heme oxygenase-1 (HO-1) pathway[J]. Med Sci Monit, 2020, 26: e921905.
[19]LI Y, TANG J, GAO H, et al. Ganoderma lucidum triterpenoids and polysaccharides attenuate atherosclerotic plaque in high-fat diet rabbits[J]. Nutr Metab Cardiovasc Dis, 2021, 31(6): 1929-1938.
[20]KAHVECI R, KAHVECI F O, GOKCE E C, et al. Effects of Ganoderma lucidum polysaccharides on different pathways involved in the development of spinal cord ischemia reperfusion injury: biochemical, histopathologic, and ultrastructural analysis in a rat model[J]. World Neurosurg, 2021, 150: e287-e297.
[21]LIN D, ZHANG Y, WANG S, et al. Ganoderma lucidum polysaccharide peptides GL-PPSQ(2) alleviate intestinal ischemia-reperfusion injury via inhibiting cytotoxic neutrophil extracellular traps[J]. Int J Biol Macromol, 2023, 244: 125370.
[22]LI Y, LIANG W, HAN Y, et al. Triterpenoids and polysaccharides from Ganoderma lucidum improve the histomorphology and function of testes in middle-aged male mice by alleviating oxidative stress and cellular apoptosis[J]. Nutrients, 2022, 14(22):4733.
[23]ZHAO Y, LI Q, WANG M, et al. Structural characterization of polysaccharides after fermentation from Ganoderma lucidum and its antioxidant activity in HepG2 cells induced by H(2)O(2)[J]. Food Chem X, 2023, 18: 100682.
[24]VEENA R K, JANARDHANAN K K. Polysaccharide-protein complex isolated from fruiting bodies and cultured mycelia of lingzhi or reishi medicinal mushroom, Ganoderma lucidum (Agaricomycetes), attenuates doxorubicin-induced oxidative stress and myocardial injury in rats[J]. Int J Med Mushrooms, 2022, 24(2): 31-40.
[25]FANG H, LIN D, LI X, et al. Therapeutic potential of Ganoderma lucidum polysaccharide peptide in Doxorubicin-induced nephropathy: modulation of renin-angiotensin system and proteinuria[J]. Front Pharmacol, 2023, 14: 1287908.
[26]AHMAD M F, AHMAD F A, KHAN M I, et al. Ganoderma lucidum: a potential source to surmount viral infections through β-glucans immunomodulatory and triterpenoids antiviral properties[J]. Int J Biol Macromol, 2021, 187: 769-779.
[27]MENG M, YAO J, ZHANG Y, et al. Potential anti-rheumatoid arthritis activities and mechanisms of Ganoderma lucidum polysaccharides[J]. Molecules, 2023, 28(6):2483.
[28]GUO C, GUO D, FANG L, et al. Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon[J]. Carbohydr Polym, 2021, 267: 118231.
[29]SONG M, LI Z H, GU H S, et al. Ganoderma lucidum spore polysaccharide inhibits the growth of hepatocellular carcinoma cells by altering macrophage polarity and induction of apoptosis[J]. J Immunol Res, 2021, 2021: 6696606.
[30]LIU X, YANG L, LI G, et al. A novel promising neuroprotective agent: Ganoderma lucidum polysaccharide[J]. Int J Biol Macromol, 2023, 229: 168-180.
[31]ZHOU Z Y, TANG Y P, XIANG J, et al. Neuroprotective effects of water-soluble Ganoderma lucidum polysaccharides on cerebral ischemic injury in rats[J]. J Ethnopharmacol, 2010, 131(1): 154-164.
[32]GUO S S, CUI X L, RAUSCH W D. Ganoderma lucidum polysaccharides protect against MPP(+) and rotenone-induced apoptosis in primary dopaminergic cell cultures through inhibiting oxidative stress[J]. Am J Neurodegener Dis, 2016, 5(2): 131-144.
[33]LI H, XIAO Y, HAN L, et al. Ganoderma lucidum polysaccharides ameliorated depression-like behaviors in the chronic social defeat stress depression model via modulation of Dectin-1 and the innate immune system[J]. Brain Res Bull, 2021, 171: 16-24.
[34]WANG S Q, LI X J, QIU H B, et al. Anti-epileptic effect of Ganoderma lucidum polysaccharides by inhibition of intracellular calcium accumulation and stimulation of expression of CaMKII α in epileptic hippocampal neurons[J]. PLoS One, 2014, 9(7): e102161.
[35]苏保洲. 灵芝的现代临床应用探索[J]. 现代中西医结合杂志, 2019, 28(5): 567-570.
[36]NARAYANAN S, DE MORES A R, COHEN L, et al. Medicinal mushroom supplements in cancer: a systematic review of clinical studies[J]. Curr Oncol Rep, 2023, 25(6): 569-587.
[37]SARGOWO D, OVIANTI N, SUSILOWATI E, et al. The role of polysaccharide peptide of Ganoderma lucidum as a potent antioxidant against atherosclerosis in high risk and stable angina patients[J]. Indian Heart J, 2018, 70(5): 608-614.
[38]KLUPP N L, KIAT H, BENSOUSSAN A, et al. A double-blind, randomised, placebo-controlled trial of Ganoderma lucidum for the treatment of cardiovascular risk factors of metabolic syndrome[J]. Sci Rep, 2016, 6: 29540.