实用老年医学

实用老年医学 ›› 2021, Vol. 35 ›› Issue (5): 487-490.doi: 10.3969/j.issn.1003-9198.2021.05.014

• 临床研究 • 上一篇    下一篇

参冬犀黄汤对老年胸部肿瘤放疗病人放射性肺炎的疗效及细胞因子水平的影响

吕青, 陈燕春, 朱国民, 陈胜东, 王达飞   

  1. 214200 江苏省无锡市,宜兴市肿瘤医院放疗中心
  • 收稿日期:2020-06-02 出版日期:2021-05-20 发布日期:2021-05-25
  • 通讯作者: 王达飞,Email:dafeiwang@163.com
  • 基金资助:
    宜兴市科技创新科技发展类专项资金项目(2018SF21 )

Effect of Shendong Xihuang Decoction on radiation pneumonitis and serum levels of cytokines in elderly patients with thoracic malignancies undergoing radiotherapy

LYU Qing, CHEN Yan-chun, ZHU Guo-min, CHEN Sheng-dong, WANG Da-fei   

  1. Department of Radiotherapy, Cancer Hospital of Yixing City, Wuxi 214206, China
  • Received:2020-06-02 Online:2021-05-20 Published:2021-05-25

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摘要： 目的 观察参冬犀黄汤对接受放疗的老年胸部肿瘤病人放射性肺炎的治疗作用及对病人血清中IL-6、转化生长因子β1(TGF-β1)、TNF-α表达水平的影响。方法 68例入组病人随机分为对照组和治疗组,每组34例。2组病人均接受胸部放疗,治疗组在放疗过程中予以口服参冬犀黄汤。观察2组病人治疗前后的一般情况、放射性肺炎的发生率及严重程度,检测不同时间点血清中IL-6、TGF-β1、TNF-α的表达水平。结果 放疗结束时,治疗组生活质量改善情况优于对照组(P＜0.05)。治疗组放射性肺炎的发生率显著低于对照组(22.22%比64.71%,P＜0.05),3级以上放射性肺炎病人比例较对照组低(5.56%比29.41%,P＜0.05)。2组病人血清IL-6、TGF-β1、TNF-α水平在放疗结束时均升高,对照组升高更显著(P＜0.05);放疗后3个月再次检测,2组上述指标均较前下降,但对照组仍高于治疗组(P＜0.05)。结论 参冬犀黄汤能够降低老年肿瘤病人放射性肺炎的发生率及严重程度,并改善病人的生存质量,其作用机制可能是抑制细胞因子IL-6、TGF-β1、TNF-α水平。

关键词: 参冬犀黄汤, 放射性肺炎, 白细胞介素6, 转化生长因子β1, 肿瘤坏死因子α

Abstract: Objective To observe the clinical efficacy of Shendong Xihuang Decoction against radiation pneumonitis in the elderly patients with thoracic malignancies undergoing radoitherapy and the effects on the serum levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and transforming growth factor-β1 (TGF-β1). Methods A total of 68 eligible patients were randomly divided into the control group and the experimental group, with 34 cases in each group. The control group was only treated with chest radiotherapy, while the experimental group was treated with chest radiotherapy and oral Shendong Xihuang Decoction. The patients’ general condition, incidence rate and grading-score of radiation pneumonitis were observed. The serum levels of IL-6, TNF-α and TGF-β1 before treatment, at the end of radiotherapy and 3 months after radiotherapy in the two groups were detected and compared. Results At the end of radiotherapy, the quality of life in the experimental group was better than that in the control group(P＜0.05). The incidence rate of radiation pneumonitis and the percentage of grade-3 and grade-4 radiation pneumonitis in the experimental group were significantly lower than those in the control group (22.22% vs 64.71%, 5.56% vs 29.41%, all P＜0.05). During the period of radiation treatment, the serum levels of IL-6, TGF-β1 and TNF-α increased significantly at the end of radiotherapy in the two groups, especially in the control group(P＜0.05), and decreased significantly 3 months after radiotherapy, especially in the experimental group (P<0.05). Conclusions Shendong Xihuang Decoction could reduce the incidence rate and the grade of radiation pneumonia in the elderly patients with thoracic malignancies. It has favorable effects in improving their quality of life. The potential mechanism may be related with reducing the serum levels of IL-6, TNF-α, TGF-β1.

Key words: Shendong Xihuang Decoction, radiation pneumonitis, interleukin-6, tumor necrosis factor-α, transforming growth factor-β1

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