实用老年医学

实用老年医学 ›› 2021, Vol. 35 ›› Issue (8): 849-851.doi: 10.3969/j.issn.1003-9198.2021.08.015

• 临床研究 • 上一篇    下一篇

钙化性心瓣膜病合并肺动脉高压病人血清miR-222、白细胞介素-6、脑钠肽水平分析

周华兰, 林森, 李霞, 徐培敬, 胡有东   

  1. 223002 江苏省淮安市,徐州医科大学附属淮安医院老年科(周华兰,李霞,徐培敬,胡有东);检验科(林森)
  • 收稿日期:2020-08-04 出版日期:2021-08-20 发布日期:2021-08-30
  • 基金资助:
    江苏省淮安市科技支撑计划(社会发展)项目(HAS2010034)

Analysis of serum levels of miR-222, interleukin-6 and brain natriuretic peptide in patients with calcified valvular heart disease and pulmonaryarterial hypertension

ZHOU Hua-lan, LI Xia, XU Pei-jing, HU You-dong   

  1. Department of Clinical Laboratory, the Huai'an Hospital Affiliated to Xuzhou Medical University, Huai'an 223002,China
  • Received:2020-08-04 Online:2021-08-20 Published:2021-08-30

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摘要： 目的 探讨钙化性心瓣膜病(calcified valvular heart disease,CVHD)合并肺动脉高压(pulmonary arterial hypertension,PH)病人微小RNA-222(miR-222)、IL-6、hs-CRP、N末端脑钠肽前体(N-terminal pro-brain natriuretic peptide,NT-proBNP)的水平及其临床意义。 方法 选择2018年8月至2019年5月在我院住院的CVHD病人158例,分为单纯CVHD组(n=86)及CVHD合并PH组(n=72),另选30名健康体检者作为对照组。比较3组血清miR-222、IL-6、NT-proBNP、hs-CRP的水平差异,并分析miR-222与IL-6、NT-proBNP、hs-CRP的相关性。 结果 CVHD病人血清miR-222、IL-6、NT-proBNP、hs-CRP的水平明显升高,尤其是合并PH的CVHD病人升高更明显(P＜0.05或P＜0.01)。相关性分析显示,所有CVHD病人IL-6、NT-proBNP、hs-CRP水平与miR-222水平呈正相关(r=0.507、0.390、0.509,均P＜0.01)。 结论 血清miR-222及IL-6等介导的炎性反应参与了CVHD及其合并PH的进展及预后。

关键词: 钙化性心瓣膜病, 肺动脉高压, 微小RNAs, 白细胞介素6

Abstract: Objective To explore the serum levels of microRNA-222 (miR-222), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) and their clinical value in the patients with calcified valvular heart disease (CVHD) and pulmonaryarterial hypertension(PH). Methods A total of 158 patients with CVHD were divided into CVHD group (n=86) and CVHD combined with PH group(n=72). Thirty healthy people were selected as the control group. The serum levels of miR-222, IL-6, NT-proBNP and hs-CRP were detected and compared among the three groups, and the correlation between miR-222 and IL-6, NT-proBNP, hs-CRP was analyzed. Results The serum levels of miR-222, IL-6, NT-proBNP and hs-CRP in CVHD group increased significantly, especially in CVHD combined with PH group(P<0.05 or P＜0.01). In the patients with CVHD, the serum levels of IL-6, NT-proBNP, hs-CRP, miR-222 were all positively correlated with the level of miR-222 (r=0.507,0.390,0.509, P＜0.01). Conclusions Serum inflammatory factors such as miR-222 and IL-6 are involved in the occurrence and progression of CVHD and the development of PH.

Key words: calcified valvular heart disease, pulmonary arterial hypertension, microRNAs, interleukin-6

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