实用老年医学

实用老年医学 ›› 2021, Vol. 35 ›› Issue (4): 390-392.doi: 10.3969/j.issn.1003-9198.2021.04.018

• 临床研究 • 上一篇    下一篇

淋巴细胞/单核细胞比值预测老年结肠高危腺瘤的价值

孙洁, 马沁妍, 查秀芳, 桑楠, 苏菡, 赵君宁   

  1. 210024 江苏省南京市,南京医科大学附属老年医院消化内科
  • 收稿日期:2020-04-24 发布日期:2021-04-25

Lymphocyte-to-monocyte ratio in predicting high-risk colon adenomas in elderly patients

SUN Jie, MA Qin-yan, ZHA Xiu-fang, SANG Nan, SU Han, ZHAO Jun-ning   

  1. Department of Gastroenterology, Geriatric Hospital of Nanjing Medical University, Nanjing 210024, China
  • Received:2020-04-24 Published:2021-04-25

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摘要： 目的 本研究旨在观察老年人群中结肠高危腺瘤病人淋巴细胞/单核细胞比值(LMR)和其他炎症因子的变化,探讨LMR对老年结肠高危腺瘤的预测价值。方法 纳入157例行结肠镜检查的老年病人并收集相关临床资料。采用Logistic回归分析高危腺瘤的危险因素,采用ROC曲线评价LMR对结肠高危腺瘤的预测价值。结果 单因素分析表明,单核细胞计数、LMR和中性粒细胞/淋巴细胞比值(NLR)是高危腺瘤的影响因素(P <0.05)。Logistic回归分析显示,LMR是高危腺瘤的独立危险因素。ROC曲线分析表明,LMR预测高危腺瘤的灵敏度为65.6%,特异性为70.4%(AUC=0.720,P<0.001),LMR最佳截断值为4.49。结论 LMR与老年结肠高危腺瘤有关,可作为预测结肠高危腺瘤新的生物标志物。

关键词: 结肠腺瘤, 淋巴细胞/单核细胞比值, 炎症因子, 老年人

Abstract: Objective To observe the changes of lymphocyte-to-monocyte ratio (LMR) and other inflammatory factors in the elderly patients with high-risk colon adenomas, and to investigate the predictive value of LMR for high-risk colon adenomas. Methods The clinical data of 157 elderly patients who underwent colonoscopy were retrospectively collected and analyzed. Logistic regression analysis was performed to identify the risk factors of high-risk colon adenomas. Receiver operating characteristic (ROC) curve was used to evaluate the predictive efficiency of LMR for high-risk colon adenoma. Results Univariate analysis showed that monocyte count, LMR and neutrophil-to-lymphocyte ratio (NLR) were influencing factors for high-risk adenomas (P<0. 05). Logistic regression analysis revealed that LMR was an independent risk factor for high-risk adenomas. ROC curve analysis showed that LMR could predict high-risk adenomas with a critical LMR of 4. 49, with sensitivity of 65. 6%, specificity of 70. 4%, area under the curve(AUC) of 0. 720(P<0. 001). Conclusions Lower LMR is associated with high-risk colon adenomas and it can be used as a new biomarker to diagnose high-risk colon adenomas in the elderly patients.

Key words: colon adenoma, lymphocyte-to-monocyte ratio, inflammatory factors, aged

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