实用老年医学

实用老年医学 ›› 2021, Vol. 35 ›› Issue (2): 177-179.doi: 10.3969/j.issn.1003-9198.2021.02.017

• 临床研究 • 上一篇    下一篇

老年2型糖尿病肾病病人血脂与肾功能指标的变化

缪鋆鋆, 孙心怡, 贾佳, 葛静   

  1. 210029 江苏省南京市,南京中医药大学附属医院内分泌科
  • 收稿日期:2020-11-12 发布日期:2021-02-08
  • 通讯作者: 葛静,Email:gejing1223@163.com
  • 基金资助:
    国家自然科学基金(81704022)

Changes of blood lipid and renal function in elderly patients with type 2 diabetic nephropathy

MIAO Jun-jun, SUN Xin-yi, JIA Jia, GE Jing   

  1. Department of Endocrinology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China
  • Received:2020-11-12 Published:2021-02-08

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摘要： 目的 探讨老年2型糖尿病肾病病人血脂与肾功能指标变化的关系。方法 选取2018年1月至2019年12月在我科门诊及住院接受治疗的≥60岁的老年糖尿病病人100例。按照尿蛋白排泄率(UAER)不同,将其划分为正常蛋白尿组、微量蛋白尿组以及大量蛋白尿组,同时选取40例老年健康体检者作为对照组。检测各组的TC、TG、HDL-C、LDL-C、BUN、肌酐(Cr)、胱抑素C(Cys-c)水平,并进行对比分析。结果 大量蛋白尿组HDL-C水平较微量蛋白尿组和正常蛋白尿组降低, Cys-c、Cr水平较微量蛋白尿组和正常蛋白尿组升高, TC、TG、BUN水平较正常蛋白尿组升高,差异有统计学意义(P<0.05)。微量蛋白尿组BUN较正常蛋白尿组升高,差异有统计学意义(P<0.05)。结论 老年糖尿病肾病病人的TC、TG、Cys-c水平升高,HDL-C水平降低。Cys-c可以作为肾脏更早期损伤的一个重要监测指标。

关键词: 糖尿病肾病, 蛋白尿, 血脂

Abstract: Objective To investigate the relationship between blood lipid and renal function in the elderly patients with type 2 diabetic nephropathy(DN). Methods From January 2018 to December 2019, 100 cases of elderly diabetic patients aged over 60 years old were selected. According to the levels of urinary albumin excretion rate (UAER), they were divided into normal albuminuria group, microalbuminuria group and massive albuminuria group. At the same time, 40 healthy elderly people were selected as the control group. The levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), urea nitrogen (BUN), creatinine (Cr), Cystatin C (Cys-c) in each group were compared. Results Compared with the microalbuminuria group and normal albuminuria group, the level of HDL-C decreased and the levels of Cys-c, Cr increased significantly in the massive albuminuria group. Compared with the normal albuminuria group, the levels of TC,TG,BUN increased in the massive albuminuria group(P<0. 05), and the level of BUN increased in the microalbuminuria group(P<0. 05). Conclusions The levels of TC, TG and Cys-c increase and the level of HDL-C decreases in the patients with DN. The level of Cys-c can be used as an important indicator of early renal damage in the elderly patients with DN.

Key words: diabetic nephropathy, proteinuria, blood lipid

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