Abstract: Objective To analyze the association between serum osteocalcin and muscle mass in overweight elderly male. Methods A total of 167 overweight elderly male patients admitted to Department of Geriatrics, Nanjing Drum Towel Hospital from January 2020 to December 2022 were enrolled in this study. The subjects were classified into low osteocalcin group and normal osteocalcin group based on the serum level of osteocalcin.The relationship between the serum level of osteocalcin and lumbar and hip muscle masses was analyzed. Multiple linear regression analysis was used to analyze the influencing factors of muscle mass. Results Significant differences were observed in age and the levels of glycosylated hemoglobin A1c (HbA1c), type Ⅰ collagen cross-linked C-terminal peptide (CTX), type Ⅰ procollagen amino terminal peptide (P1NP), 25-hydroxy vitamin D, waist muscle mass and hip muscle mass between the two groups (all P<0.05). The lumbar muscle mass and hip muscle mass were positively correlated with the levels of osteocalcin, CTX and P1NP(r=0.204-0.322, all P<0.05), and negatively correlated with age, BMI and abdominal circumference (r=-0.282--0.187, all P<0.05). Multiple linear regression analysis showed that age and abdominal circumference were the independent influencing factors of hip muscle mass (β=-0.081 and -0.127, both P<0.05), while age, abdominal circumference and osteocalcin were the independent influencing factors of lumbar muscle mass (β=-0.201,-0.136, 0.187, all P<0.05). Conclusions There are positive correlations between lumbar and hip muscle masses and serum level of osteocalcin in overweight elderly male patients. Furthermore, osteocalcin is an independent influencing factor of lumbar muscle mass.

Key words: elderly male, overweight, muscle mass, osteocalcin