尿酸对老年膝骨关节炎病人软骨GLUT9、URAT1表达的影响

doi:10.3969/j.issn.1003-9198.2023.03.018

Abstract

Abstract: Objective To investigate the correlation between serum uric acid (UA)level and the expression of UA transporter protein of cartilage tissue in the elderly patients with knee osteoarthritis(KOA). Methods A totoal of 30 elderly patients with KOA in the Department of Orthopedics, Hebei General Hospital from January 2018 to December 2019 were enrolled. According to the median level of UA, the patients were divided into UA＜254.6 μmol/L group (group A) and UA≥254.6 μmol/L group (group B). The expression levels of glucose transporter 9 polypeptide (GLUT9) and urate transporter 1(URAT1) in cartilage tissue in the two groups were detected and compared. Results The levels of weight and body mass index(BMI), and visual analogue scale (VAS) score in group A were significantly lower than those in group B (P<0.05). Pearson analysis showed that VAS score was positively correlated with UA level(r=0.396,P＜0.05). Compared with group A, the expression levels of GLUT9 and URAT1 mRNA and protein were significantly increased in group B (P<0.05). Conclusions The increase of UA level may increase the expression of GLUT9 and URAT1 protein in cartilage and the level of UA in chondrocytes, which induces the oxidative damage of chondrocytes, thereby participating in the pathogenesis of KOA.

Key words: uric acid, knee osteoarthritis, glucose transporter 9 polypeptide, urate transporter 1

CLC Number:

R 681

ZHANG Xue-mei, WANG Zhong-li, WANG Chao, HUANG Teng, ZHANG Kai, NIE Qian, SONG Guang-yao. Effects of uric acid on the expression of GLUT9 and URAT1 of cartilage in elderly patients with knee osteoarthritis[J]. Practical Geriatrics, 2023, 37(3): 287-290.

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Effects of uric acid on the expression of GLUT9 and URAT1 of cartilage in elderly patients with knee osteoarthritis

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