Abstract: Objective To analyze the clinical value of 25-hydroxyvitamin D [25(OH)D], serum tartrate-resistant acid phosphatase 5b (TRACP-5b), type Ⅰprocollagen amino-terminal propeptide (PINP) and β-isomerized C-terminal telopeptides (β-CTX) in the diagnosis of postmenopausal osteoporosis (OP). Methods A total of 150 patients diagnosed as postmenopausal OP (T≤-2.5 SD) in our hospital from March 2019 to July 2021 were selected as the OP group, and 150 postmenopausal women with normal bone mass density (BMD) during physical examination at the same period were selected as the control group. The levels of BMD, 25(OH)D, TRACP-5b, PINP and β-CTX were detected in all subjects. The relationship of all indexes of bone metabolism with OP were analyzed by Logistic regression, and the receiver operating characteristic(ROC) curve was drawn to evaluate the diagnostic value of 25(OH)D, TRACP-5b, PINP and β-CTX for OP. Results The serum levels of BMD and 25(OH)D in the OP group were significantly lower, and the serum levels of TRACP-5b, PINP and β-CTX were significantly higher than those in the control group. Pearson correlation analysis showed that serum level of 25(OH)D was positively correlated with BMD, and the levels of TRACP-5b, PINP and β-CTX were negatively correlated with BMD in the OP patients. Logistic regression analysis showed that the decrease of serum 25(OH)D and the increase of TRACP-5b, PINP and β-CTX may be the influencing factors for the occurrence of postmenopausal OP. ROC curve analysis showed that the efficiency of the above four indicators alone for diagnosing OP was 0.82, 0.87, 0.82, 0.70, respectively, and the combined diagnostic efficiency reached 0.90. Conclusions Serum levels of 25(OH)D, TRACP-5b, PINP and β-CTX can be used in combination to diagnose postmenopausal OP, and can provide some basis for clinical prevention and intervention.

Key words: postmenopausal osteoporosis, 25-hydroxyvitamin D, tartrate-resistant acid phosphatase 5b, typeⅠprocollagen amino-terminal propeptide, β-isomerized C-terminal telopeptides