组织弹性成像硬度预测药物治疗老年良性前列腺增生病人夜尿症状的效果

doi:10.3969/j.issn.1003-9198.2022.08.009

Abstract

Abstract: Objective To investigate the evaluation value of prostatic tissue elastography stiffness on the efficacy of α-receptor blockers in the treatment of nocturia in the elderly patients with benign prostatic hyperplasia (BPH). Methods The clinical data of 136 BPH patients aged > 60 years old who were treated with α-receptor blockers for nocturia were prospectively collected, including age, body mass index (BMI), International Meniscus Symptom Score (IPSS), IPSS voiding symptom score (IPSSv), IPSS stored symptom scores (IPSSs), and maximum urinary flow rate (Qmax) obtained by urodynamic examination; Total prostate volume (TPV), transitional zone volume (TZV), residual urine volume (PVR), and real-time shear wave elastography (SWE) of prostate transitional zone tissue were measured by transrectal ultrasound to obtain the elastic modulus (Emean). Logistic regression was used to analyze the factors influencing the improvement of nocturia after administration. Results Of the 136 patients, 54 (39.7%) cases showed improvement of nocturia. Compared with the patients without improvement of nocturia, the patients in the improvement group had smaller age, TPV, TZV, Qmax and Emean, with statistically significant differences (P<0.05); While the levels of BMI, IPSS, IPSSv, IPSSs and PVR showed no significant differences between the two groups (P>0.05). Multivariate Logistic analysis showed that age (OR=2.837,95%CI:1.352-5.827) and Emean (OR=4.258,95%CI:2.065-8.710) were the independent factors for improvement of nocturia in BPH patients. The area under the receiver operating characteristic curve of Emean for predicting the improvement of nocturia after medication in the elderly patients with BPH was 0.747 (95% CI: 0.628-0.852), with an optimal cut-off point of 38.4 kPa, and the sensitivity and specificity was 74.14% and 70.68%, respectively. Conclusions Prostate tissue elastography stiffness can predict the therapeutic effect of α-receptor blockers in the treatment of BPH nocturia.

Key words: prostatic hyperplasia, elastography, predictive value, nocturia

CLC Number:

R697.32

LI Shao-lei, DING Yan, WU Peng-xi, HU Qiang, RUAN Jun, WANG Yong. Evaluation of the effect of alpha-receptor blockers on nocturia in elderly patients with benign prostatic hyperplasia using elastography[J]. Practical Geriatrics, 2022, 36(8): 788-790.

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Evaluation of the effect of alpha-receptor blockers on nocturia in elderly patients with benign prostatic hyperplasia using elastography

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