Practical Geriatrics

Practical Geriatrics ›› 2026, Vol. 40 ›› Issue (5): 505-509.doi: 10.3969/j.issn.1003-9198.2026.05.014

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Pridictive value of LDL-C/HDL-C ratio in elderly patients with colorectal adenoma and construction of a nomogram prediction model

SUN Jie, SANG Nan, FAN Yao, YANG Yan, ZHAO Junning, WANG Wei   

  1. Department of Gastroenterology (SUN Jie, SANG Nan, YANG Yan, ZHAO Junning); Clinical Epidemiology Research Laboratory (FAN Yao); Chronic Disease and Health Management Research Center (WANG Wei), Jiangsu Province Official Hospital, Nanjing 210024, China
  • Received:2025-11-17 Published:2026-05-20
  • Contact: WANG Wei, Email: wangwei16306@163.com

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Abstract: Objective To explore the association between LDL-C/HDL-C ratio (LHR) and colorectal adenoma (CRA) in the elderly, and to construct and validate a nomogram prediction model suitable for non-invasive risk assessment of CRA in the elderly, thereby mitigating the limitations of colonoscopy screening. Methods A total of 329 elderly individuals were enrolled in this study, comprising 194 participants in the adenoma group and 135 cases in the non-adenoma group. Baseline demographic and clinical data were collected, including age, body mass index (BMI), glycated hemoglobin (HbA1c), Helicobacter pylori infection (Hp+), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), and total cholesterol (TC). The lipid ratios LDL-C/HDL-C (LHR) and TG/HDL-C (THR), as well as the derived index (TC-HDL-C)/HDL-C (NHHR), were calculated. Binary logistic regression analysis was performed to identify independent risk factors for CRA. The predictive ability of the model was assessed using receiver operating characteristic (ROC) curve analysis, net reclassification improvement (NRI), integrated discrimination improvement (IDI), and decision curve analysis (DCA). Results Significant differences between the adenoma and non-adenoma groups were observed in age, BMI, HbA1c, Hp+, presence of fatty liver, LHR, THR, and NHHR (P<0.05). Binary logistic regression analysis revealed that age(OR=1.049)、BMI(OR=1.176)、Hp+(OR=1.989)、LHR(OR=2.689), and HbA1c(OR=1.684) were independent predictors of CRA in the elderly (all P<0.05). The area under the ROC curve (AUC) for the model incorporating LHR was 0.716, which was significantly higher than that of the model without LHR (AUC=0.697). NRI and IDI analyses further demonstrated that inclusion of LHR improved the model’s risk predictive capacity (P=0.006). Conclusions LHR is independently associated with CRA. The prediction model incorporating LHR significantly improves the risk predictive capability for CRA in the elderly.

Key words: colorectal adenoma, LDL-C/HDL-C ratio, predictive model, aged

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