Abstract: Objective To evaluate the efficacy and safety of drug-coated balloons (DCB) in the treatment for Medina 0,0,1 coronary bifurcation lesion. Methods A total of 81 consecutive patients with Medina 0,0,1 coronary bifurcation lesion who were admitted to our hospital from January 2018 to June 2021 were enrolled in this study, and the clinical features, treatment and follow-up results were collected and analyzed. Results Among the 81 patients, there were 58 males and 23 females, with a mean age of 70.1±7.1 years old; Nine cases presented with ST-elevation myocardial infarction, 7 cases with non ST-elevation myocardial infarction, 55 cases with unstable angina and 10 cases with stable angina. Coronary angiography showed that ostial circumflex was involved in 29 cases, ostial diagonal was involved in 44 cases, ostial obtuse marginal was involved in 4 cases, and ostial posterior lateral was involved in 4 cases. The lesion length was 18.98±6.40 mm, the DCB length was 20.38±3.26 mm and the acute lumen gain was 1.12±0.32 mm after procedure. The late lumen loss was 0.02±0.32 mm during angiographic follow-up. Drug-eluting stent (DES) were used in 5 cases because of severe coronary dissection. During the follow-up, 4 patients underwent target revascularization, including 3 cases after DCB treatment and 1 case after salvage stent treatment. There were no death and myocardial infarction during the follow-up. Conclusions DCB treatment for Medina 0,0,1 coronary bifurcation lesions is effective and safe, but further studies are still needed to demonstrate the results.

Key words: small branch ostial lesions, drug-coated balloons, percutaneous coronary intervention