Abstract: Objective To study the effect of donepezil combined with ginkgo biloba tablet for moderate to severe Alzheimer’s disease (AD). Methods From June 2017 to June 2019, 98 elderly patients with moderate to severe AD were selected as the research subjects. All the patients were randomly divided into two groups according to random number table method, including 49 patients in the control group (receiving donepezil) and 49 patients in observation group (receiving donepezil + ginkgo biloba). The changes of Min-Mental State Examination (MMSE), Barthel Index (BI), the Neuropsychiatric Inventory (NPI) before and after treatment were compared between the two groups. The incidence rate of adverse reaction during treatment was compared between the two groups. Results After treatment, the scores of MMSE and BI in both groups were significantly increased, and the score of NPI was significantly decreased, especially in the observation group(P<0. 05). The difference of the incidence rate of adverse reactions between the two groups was not statistically significant (P>0. 05). Conclusions Donepezil combined with ginkgo biloba tablet is reliable and effective in the treatment of moderate to severe Alzheimer’s disease.

Key words: donepezil, ginkgo biloba tablet, Alzheimer’s disease