高原地区藏、汉族轻度认知障碍与阿尔茨海默病病人血清氧化低密度脂蛋白和髓过氧化物酶的水平

doi:10.3969/j.issn.1003-9198.2021.01.005

Abstract

Abstract: Objective To investigate the relationship between the levels of serum oxidized low-density lipoprotein (oxLDL) and myeloperoxidase (MPO) and the incidence of mild cognitive impairment (MCI) and Alzheimer's disease (AD) in Tibetan and Han nationality people at high altitude. Methods The data of 60 patients with MCI, 60 patients with AD and 60 heathly normal control people (NC) of Tibetan and Han nationality living in Xining city of Qinghai Province were collected, with 30 cases in each ethnic subgroup. The cognitive function was assessed with Mini-Mental State Examination (MMSE). The levels of serum oxLDL and MPO were measured by enzyme linked immunosorbent assay. Spearman correlation analysis was performed to evaluate the relationship between the levels of oxLDL and MPO and the score of MMSE. Multivariate Logistic regression analysis was used to screen the risk factors of MCI and AD in Tibetan and Han nationality people. Results The level of oxLDL was significantly higher in Tibetan NC group than that in Han NC group (P<0. 05), and also significantly higher in Tibetan AD group than that in Han AD group (P<0. 01). The level of oxLDL in Tibetan NC group and Tibetan MCI group was significantly lower than that in Tibetan AD group (P<0. 01). The level of MPO was significantly higher in Han AD group than that in Han NC group (P<0. 05), and also significantly higher in Tibetan AD group than that in Tibetan MCI group (P<0. 01). There was a negative correlation between oxLDL level and MMSE score in Han nationality people (r=-0. 737, P<0. 001). The levels of oxLDL and MPO were both negatively related with MMSE score in Tibetan nationality people (r=-0. 794, P<0. 001; r=-0. 742, P<0. 001). Multivariate Logistic regression analysis showed that the increase of oxLDL was an independent risk factor for MCI and AD in the two nationalities, and the increase of MPO was an independent risk factor for MCI and AD in Tibetan nationality. Conclusions The cognitive function of Tibetan and Han nationality people at high altitude is related to serum oxLDL and MPO levels. It is important to monitoring the levels of oxLDL and MPO for screening the risk people.

Key words: oxidized low-density lipoprotein, myeloperoxidase, mild cognitive impairment, Alzheimer's disease, high altitude, Tibetan nationality

CLC Number:

R 749.16

JI Lei, ZHONG Xin, DU Can, LI Guo-feng, LI Hong-juan, ZHU Ai-qin. Levels of serum oxidized low-density lipoprotein and myeloperoxidase in Tibetan and Han nationality people with mild cognitive impairment and Alzheimer's disease at high altitude[J]. Practical Geriatrics, 2021, 35(1): 15-19.

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Levels of serum oxidized low-density lipoprotein and myeloperoxidase in Tibetan and Han nationality people with mild cognitive impairment and Alzheimer's disease at high altitude

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