基于肌少-骨质疏松症的Hippo通路调控间充质干细胞分化的研究进展

doi:10.3969/j.issn.1003-9198.2025.06.019

实用老年医学 ›› 2025, Vol. 39 ›› Issue (6): 626-630.doi: 10.3969/j.issn.1003-9198.2025.06.019

基于肌少-骨质疏松症的Hippo通路调控间充质干细胞分化的研究进展

高迪, 陈仁场, 梁松林, 汪陈莫及, 李念虎

250014 山东省济南市,山东中医药大学第一临床医学院(高迪,陈仁场,梁松林,汪陈莫及);250014 山东省济南市,山东中医药大学附属医院脊柱脊髓科(李念虎)

收稿日期:2024-10-21 出版日期:2025-06-20 发布日期:2025-07-07
通讯作者: 李念虎,Email:tigerlee073@126.com
基金资助:
山东省自然科学基金资助项目(ZR2023MH063)

Research progress of Hippo pathway in regulating the differentiation of mesenchymal stem cells based on osteo-sarcopenia

GAO Di, CHEN Renchang, LIANG Songlin, WANG Chenmoji, LI Nianhu

the First Clinical Medical College of Shandong University of Traditional Chinese Medicine, Jinan 250014, China(GAO Di,CHEN Renchang, LIANG Songlin, WANG Chenmoji);Department of Spine and Spinal Cord, Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014, China(LI Nianhu)

Received:2024-10-21 Online:2025-06-20 Published:2025-07-07
Contact: LI Nianhu, Email:tigerlee073@126.com

摘要/Abstract

摘要： Hippo信号通路在调控细胞和组织生长方面起着重要的作用,通过其下游转录效应因子Yes相关蛋白(YAP)与含WW结构域的转录调节因子(TAZ)对某些细胞谱系特异性转录因子进行调控,从而影响间充质干细胞(MSCs)向成骨、成脂、成肌不同方向分化。肌少-骨质疏松症的基本病理是肌肉和骨骼的脂肪浸润介导的脂肪毒性,继而导致肌力下降、骨折风险增加。由此可见,肌少-骨质疏松症的发生与骨、骨骼肌和脂肪有着密不可分的联系。本文对Hippo信号通路中的不同效应因子对于MSCs向成骨、成脂、成肌方向分化的作用机制进行综述,以期深入理解Hippo信号通路功能,并为肌少-骨质疏松症的临床治疗提供理论参考。

关键词: Hippo信号通路, 间充质干细胞, 肌少-骨质疏松症

Abstract: Hippo signaling pathway plays an important role in the regulation of cell and tissue growth. Hippo signaling pathway regulates certain cell lineage-specific transcription factors through its downstream transcriptional effectors of Yes-associated protein (YAP) and WW domain-containing transcriptional regulator (TAZ). Thus, it affects the differentiation of mesenchymal stem cells (MSCs) into osteogenic, adipogenic and myogenic directions. The basic pathology of osteo-sarcopenia (OS) is lipotoxicity mediated by fatty infiltration of muscle and bone, which in turn leads to decreased muscle strength and increased risk of fracture. It can be seen that the occurrence of OS is closely related to bone, skeletal muscle and fat. This article analyzes and reviews the pathways of different effectors in Hippo signaling pathway for the differentiation of MSCs into osteogenic, adipogenic and myogenic directions, in order to understand the function of Hippo signaling pathway and provide theoretical reference for the clinical treatment of OS.

Key words: Hippo signaling pathway, mesenchymal stem cells, osteo-sarcopenia

中图分类号:

R681
R685

高迪, 陈仁场, 梁松林, 汪陈莫及, 李念虎. 基于肌少-骨质疏松症的Hippo通路调控间充质干细胞分化的研究进展[J]. 实用老年医学, 2025, 39(6): 626-630.

GAO Di, CHEN Renchang, LIANG Songlin, WANG Chenmoji, LI Nianhu. Research progress of Hippo pathway in regulating the differentiation of mesenchymal stem cells based on osteo-sarcopenia[J]. Practical Geriatrics, 2025, 39(6): 626-630.

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基于肌少-骨质疏松症的Hippo通路调控间充质干细胞分化的研究进展

Research progress of Hippo pathway in regulating the differentiation of mesenchymal stem cells based on osteo-sarcopenia

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