躯体复原力对衰弱发生发展的影响及干预潜力

doi:10.3969/j.issn.1003-9198.2026.06.004

摘要/Abstract

摘要： 衰弱是老年人群体中高发的临床综合征,以生理储备减少、应激易感性增加为核心特征,可显著增加跌倒、失能及死亡风险。躯体复原力作为个体应对内外压力源的动态适应能力,与衰弱的发生、发展及转归存在密切关联。本文系统梳理躯体复原力的概念维度,从细胞分子、组织器官及系统协同等层面深入剖析其影响衰弱进程的生理与病理机制,并基于此总结了运动、营养及心理等多维度干预策略的研究证据。本综述旨在展望未来研究方向,为通过提升躯体复原力延缓或改善衰弱提供理论依据与实践参考。

关键词: 老年人, 躯体复原力, 衰弱, 干预潜力

Abstract: Frailty is a highly prevalent clinical syndrome among the elderly population, defined by diminished physiological reserve and heightened susceptibility to stressors. This condition substantially increases the risk of falls, disability, and mortality. As a dynamic adaptive capacity enabling individuals to cope with internal and external stressors, physical resilience is closely intertwined with the onset, progression, and outcome of frailty. In this review, we systematically synthesize the conceptual dimensions of physical resilience and comprehensively dissect the physiological and pathological mechanisms through which it modulates the frailty trajectory—spanning cellular and molecular pathways, tissue and organ function, and systemic crosstalk. Building on these mechanisms, we summarize the current research evidence supporting multidimensional intervention strategies, including exercise, nutrition, and psychological interventions. The primary objective of this work is to outline future research directions and provide a theoretical foundation as well as practical implications for delaying or ameliorating frailty via enhancing physical resilience.

Key words: aged, physical resilience, frailty, intervention potential

中图分类号:

R 592

马丫, 刘晓蕾. 躯体复原力对衰弱发生发展的影响及干预潜力[J]. 实用老年医学, 2026, 40(6): 556-560.

MA Ya, LIU Xiaolei. Effect of physical resilience on the occurrence and development of frailty and its intervention potential[J]. Practical Geriatrics, 2026, 40(6): 556-560.

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