热带气候对东北地区老年原发性高血压病人血压、外周血microRNA-146a及Hcy的影响

doi:10.3969/j.issn.1003-9198.2024.05.009

摘要/Abstract

摘要： 目的探讨热带气候对东北地区老年原发性高血压病人血压及外周血microRNA-146a、Hcy的影响。方法选取2018年10月至2022年1月三亚中心医院收治的东北三省来三亚过冬的老年原发性高血压病人252例(研究组),同期选取三亚本地老年原发性高血压病人126例(对照组)。分别在来三亚第1周、第3个月、第6个月时测量病人血压,检测外周血microRNA-146a和Hcy水平,统计2组的血压控制率、不良反应和并发症发生情况。结果第6个月时,研究组的血压控制率高于对照组(P＜0.05),且研究组第6个月时的血压控制率高于第1周时(P＜0.05)。研究组的收缩压和舒张压、microRNA-146a和Hcy水平在来三亚第1周、第3个月和第6个月时逐渐下降,差异均有统计学意义(P＜0.05)。在第3个月和第6个月时,研究组的收缩压和舒张压、microRNA-146a和Hcy水平均低于对照组(P＜0.05)。结论热带气候可使东北地区老年原发性高血压病人的平滑肌松弛,降低血压,从而减轻炎症反应,降低microRNA-146a及Hcy水平,减少高血压相关并发症及不良事件。

关键词: 高血压, 热带气候, microRNA-146a, 同型半胱氨酸

Abstract: Objective To investigate the influence of tropical climate on blood pressure, peripheral blood microRNA-146a and homocysteine (Hcy) in the elderly patients with essential hypertension from Northeast China. Methods A total of 252 elderly patients with essential hypertension who came to Sanya for winter from the three provinces in Northeast China and admitted to Sanya Central Hospital from October 2018 to January 2022 were enrolled as the study group, and 126 local elderly patients with essential hypertension in Sanya were enrolled as the control group. The blood pressure of all patients were measured and the levels of peripheral blood microRNA-146a and Hcy were detected at the time of the 1st week, the 3rd month and the 6th month in Sanya, and the control rate of hypertension and the incidence rate of adverse reactions and complications were observed and compared between the two groups. Results After 6 months of treatment, the control rate of hypertension in the study group was higher than that in the control group (P<0.05), and was higher than that after 1 week of treatment in the study group (P<0.05). The systolic and diastolic blood pressure, the levels of peripheral blood microRNA-146a and serum Hcy in the study group decreased gradually from the 1st week, the 3rd month to the 6th month (P<0.05). After 3 months and 6 months of treatment, the systolic and diastolic blood pressure, the levels of peripheral blood microRNA-146a and serum Hcy in the study group were lower than those in the control group (P<0.05). Conclusions The tropical climate can relax the smooth muscles of elderly patients with essential hypertension from Northeast China, decrease blood pressure, reduce inflammatory reactions and lower microRNA-146a and Hcy. Thus, the complications and adverse events related to hypertension can be reduced.

Key words: hypertension, tropical climate, microRNA-146a, homocysteine

中图分类号:

R 544.1

王超, 陈晓君. 热带气候对东北地区老年原发性高血压病人血压、外周血microRNA-146a及Hcy的影响[J]. 实用老年医学, 2024, 38(5): 470-437.

WANG Chao, CHEN Xiaojun. Influence of tropical climate on blood pressure, peripheral blood microRNA-146a and Hcy in elderly patients with essential hypertension from northeast China[J]. Practical Geriatrics, 2024, 38(5): 470-437.

参考文献

[1] NARITA K, HOSHIDE S, KARIO K. Seasonal variation in blood pressure: current evidence and recommendations for hypertension management[J]. Hypertens Res, 2021, 44(11):1363-1372.
[2] PARK S, KARIO K, CHIA Y C, et al. The influence of the ambient temperature on blood pressure and how it will affect the epidemiology of hypertension in Asia[J]. J Clin Hypertens, 2020, 22(3):438-444.
[3] 李志芳, 方红城, 董丽妍, 等. 高血压患者正规治疗前后夏冬季节昼夜血压变化观察[J]. 心血管康复医学杂志, 2020, 29(3):377-382.
[4] PICÓN Y A, LOZADA I D, JANJUA T, et al. Impact of time of day and season on outcome in acute ischemic stroke[J]. Ann Neurol, 2021, 90(3):518-519.
[5] ZHAO Z, SUN W, GUO Z, et al. Mechanisms of lncRNA/microRNA interactions in angiogenesis[J]. Life Sci, 2020, 254:116900.
[6] TAO J, XIA L, CAI Z, et al. Interaction between microRNA and DNA methylation in atherosclerosis[J]. DNA Cell Biol, 2021, 40(1):101-115.
[7] XIAO S, XUE T, PAN Q, et al. MicroRNA-146a serves as a biomarker for adverse prognosis of ST-segment elevation myocardial infarction[J]. Cardiovasc Ther, 2021, 10(25):2923-2941.
[8] 中国高血压防治指南修订委员会, 高血压联盟, 中华医学会心血管病学分会, 等. 中国高血压防治指南(2018年修订版)[J]. 中国心血管杂志, 2019, 24(1):24-56.
[9] 张翠真, 袁小龙, 陈志和, 等. 基于磁珠的核酸快速提取和纯化[J]. 生物学杂志, 2019, 36(4):97-101.
[10] TIKHONOFF V, CASIGLIA E. Body, indoor, outdoor temperature-and arterial blood pressure[J]. J Hypertens, 2021, 39(5):861-863.
[11] 蒲宏伟, 陈漠水, 刘文举, 等. 海南“候鸟”老年高血压患者降血压治疗疗效及相关炎症因子和神经功能缺损评分变化[J]. 中国老年学杂志, 2015, 35(16):4512-4514.
[12] 朱连荣, 彭志晴, 刘文徽, 等. 海南省气候对“候鸟”高血压患者炎性因子和miR-146a的短期影响[J]. 中国循环杂志, 2018, 33(8):772-776.
[13] ZHONG J H, LI J, LIU C F, et al. Retraction: effects of microRNA-146a on the proliferation and apoptosis of human osteochondrocytes by targeting TRAF6 through the NF- κB signalling pathway[J]. Biosci Rep, 2021, 41(7):578-580.
[14] LIU H, WANG H, MA J, et al. MicroRNA-146a-3p/HDAC1/KLF5/IKBα signal axis modulates plaque formation of atherosclerosis mice[J]. Life Sci, 2021, 284:119615.
[15] 李娜, 张岩, 贾营. NF-κB/RBP4信号通路与高血压患者炎症因子变化的相关性[J]. 临床和实验医学杂志, 2021, 20(24):2592-2595.
[16] SÁNCHEZ J L, CARBÓ R, BUELNA M, et al. Cold exposure aggravates pulmonary arterial hypertension through increased miR-146a-5p, miR-155-5p and cytokines TNF-α, IL-1β, and IL-6[J]. Life Sci, 2021,287: 120091.
[17] FU L, LI YN, LUO D, et al. Evidence on the causal link between homocysteine and hypertension from a meta-analysis of 40 173 individuals implementing Mendelian randomization[J]. J Clin Hypertens, 2019, 21(12):1879-1894.