实用老年医学

实用老年医学 ›› 2026, Vol. 40 ›› Issue (4): 372-376.doi: 10.3969/j.issn.1003-9198.2026.04.009

• 临床研究 • 上一篇    下一篇

体型指数与年龄相关性黄斑变性之间的关系

魏美慧, 施炜, 陈茜, 徐新荣, 潘莉   

  1. 210029 江苏省南京市,南京中医药大学附属医院眼科(魏美慧,施炜,陈茜,徐新荣);
    200029 江苏省南京市,南京中医药大学第一临床医学院(潘莉)
  • 收稿日期:2025-09-01 出版日期:2026-04-23 发布日期:2026-04-23
  • 通讯作者: 潘莉,Email:panli@njucm.edu.cn
  • 基金资助:
    国家自然科学基金资助项目(82401826);江苏省中医药管理局“高水平医院建设重点病种临床研究”项目(GSPYY2023009);江苏省中医药管理局青年人才项目(QN202414);江苏省高等学校基础科学(自然科学)研究面上项目(24KJB320012);江苏省中医院优秀青年博士计划(2024QB039);江苏省青年科技人才托举工程(JSTJ-2025-020)

Association between a body shape index and age-related macular degeneration

WEI Meihui, SHI Wei, CHEN Xi, XU Xinrong, PAN Li   

  1. Department of Ophthalmology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China(WEI Meihui, SHI Wei, CHEN Xi, XU Xinrong);
    the First Clinical College of Nanjing University of Chinese Medicine, Nanjing 210029, China (PAN Li)
  • Received:2025-09-01 Online:2026-04-23 Published:2026-04-23
  • Contact: PAN Li, Email:panli@njucm.edu.cn

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摘要： 目的 探讨体型指数(ABSI)与年龄相关性黄斑变性(AMD)患病风险的关联。 方法 基于美国国家健康与营养调查(NHANES)2005—2008年横断面数据,采用多元logistic回归模型分析ABSI与AMD之间的关系,采用限制性立方样条(RCS)探索ABSI与AMD是否存在剂量反应关系。 结果 共纳入4 874例参与者,其中AMD 365例。多元logistic回归模型调整所有变量后ABSI在(7.95～8.28)×10-2范围内仍与AMD显著相关,ABSI处于Q2四分位者较Q1四分位者AMD风险增加(OR=1.49,95%CI:1.01～2.20;P<0.05)。RCS分析显示,ABSI<8.28×10-2时,其与AMD风险呈正向关联。 结论 ABSI在一定区间内与AMD患病风险独立相关,或可作为AMD风险评估与早期筛查的潜在指标,提示肥胖管理对AMD防控具有意义。   

关键词: 年龄相关性黄斑变性, 体型指数, 肥胖

Abstract: Objective To explore the association between a body shape index (ABSI) and the risk of age-related macular degeneration (AMD). Methods Based on the cross-sectional data of the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2008, a multivariable logistic regression model considering the complex sampling design of NHANES was used to analyze the association between ABSI and AMD. The restricted cubic spline (RCS) analysis was conducted to explore the dose-response relationship between ABSI and AMD. Results A total of 4 874 participants (365 cases of AMD) were included. After adjusting for all variables in the multivariable logistic regression model, ABSI remained significantly positively associated with AMD within the range of (7.95-8.28)×10-2, the risk of AMD increased in the second quartile than that in the first quartile (OR=1.49,95%CI:1.01-2.20). RCS analysis showed that when ABSI was less than 8.28×10-2, it is positively associated with AMD risk. Conclusions ABSI is independently associated with the risk of AMD within a certain range and may serve as a potential indicator for risk assessment and early screening, which suggesting that obesity management is significant for the prevention and control of AMD.   

Key words: age-related macular degeneration, a body shape index, obesity

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