尿酸对老年膝骨关节炎病人软骨GLUT9、URAT1表达的影响

doi:10.3969/j.issn.1003-9198.2023.03.018

实用老年医学 ›› 2023, Vol. 37 ›› Issue (3): 287-290.doi: 10.3969/j.issn.1003-9198.2023.03.018

尿酸对老年膝骨关节炎病人软骨GLUT9、URAT1表达的影响

张雪梅, 王忠丽, 王超, 黄腾, 张凯, 聂倩, 宋光耀

050051 河北省石家庄市,河北省人民医院风湿免疫科(张雪梅);体检中心(王忠丽,聂倩);代谢病重点实验室(王超,宋光耀);骨科(黄腾,张凯)

收稿日期:2022-03-28 出版日期:2023-03-20 发布日期:2023-03-13
通讯作者: 宋光耀,Email:sguangyao2@163.com

Effects of uric acid on the expression of GLUT9 and URAT1 of cartilage in elderly patients with knee osteoarthritis

ZHANG Xue-mei, WANG Zhong-li, WANG Chao, HUANG Teng, ZHANG Kai, NIE Qian, SONG Guang-yao

Department of Rheumatology and Immunology(ZHANG Xue-mei); Medical Examination Center(WANG Zhong-li, NIE Qian); Key Laboratory of Metabolic Diseases(WANG Chao, SONG Guang-yao); Department of Orthopaedics(HUANG Teng, ZHANG Kai), Hebei Gerneral Hospital, Shijiazhuang 050051, China

Received:2022-03-28 Online:2023-03-20 Published:2023-03-13
Contact: SONG Guang-yao, Email: sguangyao2@163.com

摘要/Abstract

摘要： 目的探讨老年膝骨关节炎病人血清UA水平与软骨组织中UA转运蛋白的相关性。方法收集2018～2019年就诊于河北省人民医院骨科的老年膝骨关节炎(KOA)病人30例。以所有入选者UA中位数水平(254.6 μmol/L)将病人分为血清UA＜254.6 μmol/L组(A组)和UA≥254.6 μmol/L组(B组),检测并比较2组软骨组织中葡萄糖易化转运蛋白9(GLUT9)和尿酸盐转运蛋白1(URAT1)的mRNA和蛋白的表达水平。结果与B组相比,A组病人的体质量、BMI较小,VAS评分较低,差异均有统计学意义(P＜0.05)。Pearson相关分析显示,VAS评分与UA水平呈正相关(r=0.396,P＜0.05)。B组病人关节软骨中GLUT9、URAT1的mRNA和蛋白表达水平均较A组明显升高,差异有统计学意义(P＜0.05)。结论 UA水平的升高可能通过增加软骨中GLUT9及URAT1蛋白的表达,使软骨细胞内UA水平升高,诱导软骨细胞氧化损伤,从而参与KOA的发病。

关键词: 尿酸, 膝骨关节炎, 葡萄糖易化转运蛋白9, 尿酸盐转运蛋白1

Abstract: Objective To investigate the correlation between serum uric acid (UA)level and the expression of UA transporter protein of cartilage tissue in the elderly patients with knee osteoarthritis(KOA). Methods A totoal of 30 elderly patients with KOA in the Department of Orthopedics, Hebei General Hospital from January 2018 to December 2019 were enrolled. According to the median level of UA, the patients were divided into UA＜254.6 μmol/L group (group A) and UA≥254.6 μmol/L group (group B). The expression levels of glucose transporter 9 polypeptide (GLUT9) and urate transporter 1(URAT1) in cartilage tissue in the two groups were detected and compared. Results The levels of weight and body mass index(BMI), and visual analogue scale (VAS) score in group A were significantly lower than those in group B (P<0.05). Pearson analysis showed that VAS score was positively correlated with UA level(r=0.396,P＜0.05). Compared with group A, the expression levels of GLUT9 and URAT1 mRNA and protein were significantly increased in group B (P<0.05). Conclusions The increase of UA level may increase the expression of GLUT9 and URAT1 protein in cartilage and the level of UA in chondrocytes, which induces the oxidative damage of chondrocytes, thereby participating in the pathogenesis of KOA.

Key words: uric acid, knee osteoarthritis, glucose transporter 9 polypeptide, urate transporter 1

中图分类号:

R 681

张雪梅, 王忠丽, 王超, 黄腾, 张凯, 聂倩, 宋光耀. 尿酸对老年膝骨关节炎病人软骨GLUT9、URAT1表达的影响[J]. 实用老年医学, 2023, 37(3): 287-290.

ZHANG Xue-mei, WANG Zhong-li, WANG Chao, HUANG Teng, ZHANG Kai, NIE Qian, SONG Guang-yao. Effects of uric acid on the expression of GLUT9 and URAT1 of cartilage in elderly patients with knee osteoarthritis[J]. Practical Geriatrics, 2023, 37(3): 287-290.

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尿酸对老年膝骨关节炎病人软骨GLUT9、URAT1表达的影响

Effects of uric acid on the expression of GLUT9 and URAT1 of cartilage in elderly patients with knee osteoarthritis

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