实用老年医学

实用老年医学 ›› 2021, Vol. 35 ›› Issue (10): 1063-1066.doi: 10.3969/j.issn.1003-9198.2021.10.016

• 临床研究 • 上一篇    下一篇

中老年女性人群血清维生素D营养状况及其与贫血的相关性研究

杨瑞霞, 宋为娟, 崔婷, 唐未名   

  1. 210029 江苏省南京市,江苏省人民医院检验学部
  • 收稿日期:2020-12-09 出版日期:2021-10-20 发布日期:2021-10-13
  • 通讯作者: 宋为娟,Email:352699486@qq.com

Serum level of vitamin D in middle-aged and elderly women and the correlation with anemia

YANG Rui-xia, SONG Wei-juan, CUI Ting, TANG Wei-ming   

  1. Department of Laboratory Medicine, Jiangsu Province Hospital, Nanjing 210029, China
  • Received:2020-12-09 Online:2021-10-20 Published:2021-10-13

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摘要： 目的 了解中老年女性人群维生素D的营养状况,并探讨其与贫血的关系。 方法 选择2019年1月至2020年9月在江苏省人民医院体检中心进行健康体检的中老年女性人群332例,检测其血清25-羟维生素D[25-(OH)D]及红细胞参数水平。采用Spearman相关系数描述25-(OH)D与红细胞各参数的关系;采用多元线性回归分析血清25-(OH)D的独立影响因素。 结果 332例中老年女性血清25-(OH)D水平为42.60(19.10~73.10)nmol/L,其中25-(OH)D缺乏者占比69.28%,25-(OH)D不足者占比30.72%;中年组(45~59岁,n=270)的25-(OH)D水平显著高于老年组(60~79岁,n=62),差异有统计学意义(Z=-5.140,P<0.001);夏秋组(5~10月检测者,n=225)的25-(OH)D水平显著高于冬春组(11月至次年4月检测者,n=107),差异有统计学意义(Z=-5.577,P<0.001)。中、老年组中25-(OH)D不足者与25-(OH)D缺乏者的贫血率差异均无统计学意义(χ2 =3.112、1.079,P=0.078、0.299)。中年组中,25-(OH)D不足者的RBC、Hb、红细胞压积(HCT)、平均红细胞体积(MCV)、平均血红蛋白浓度(MCHC)均显著高于25-(OH)D缺乏者(P<0.05);老年组中,25-(OH)D不足者的RBC、HCT均显著高于25-(OH)D缺乏组(P<0.01)。中年组中,RBC、Hb与25-(OH)D独立相关(β=14.545、0.103,P<0.05);老年组中,RBC、HCT与25-(OH)D独立相关(β=9.939、0.672,P<0.01)。 结论 中老年女性人群普遍存在维生素D营养缺乏或不足,维生素D缺乏可影响红细胞相关参数水平。

关键词: 中老年女性, 25-羟维生素D, 贫血, 红细胞参数

Abstract: Objective To investigate the serum level of vitamin D in the middle-aged and elderly women and the correlation with anemia. Methods A total of 332 middle-aged and elderly women in Medical Examination Center of Jiangsu Province Hospital from January 2019 to September 2020 were selected. The levels of serum 25-hydroxy vitamin D [25-(OH)D] and red blood cell parameters were detected. The correlation between 25-(OH)D and red blood cell parameters was analyzed by Spearman correlation analysis. Results The serum 25-(OH)D level of 332 middle-aged and elderly women was 42.60 (19.10-73.10) nmol/L, 25-(OH)D deficiency accounting for 69.28%, 25-(OH)D insufficiency accounting for 30.72%. The level of 25-(OH)D in middle-aged group (aged 45-59 years old, n=270) was higher than that in elderly group (aged 60-79 years old, n=62), and the difference was statistically significant (Z=-5.140, P<0.001); The level of 25-(OH)D in summer to autumn group (detection from May to October, n=225) was significantly higher than that in winter to spring group (detection from November to April of the next year, n=107), and the difference was statistically significant (Z=-5.577, P<0.001). In the middle-aged group and the elderly group, there were no differences in the rate of anemia between 25-(OH)D insufficiency subgroup and 25-(OH)D deficiency subgroup (χ2 =3.112, 1.079; P=0.078, 0.299). In the middle-aged group, the levels of red blood cell (RBC), hemoglobin(Hb), hematocrit (HCT), mean corpuscular volume (MCV) and mean hemoglobin concentration (MCHC) in the 25-(OH)D insufficiency subgroup were significantly higher than those in the 25-(OH)D deficiency subgroup (P<0.05). In the elderly group, the levels of RBC and HCT in the 25-(OH)D insufficiency subgroup were significantly higher than those in the 25-(OH)D deficiency subgroup (P<0.01). In the middle-aged group, RBC and Hb were independently correlated with 25-(OH)D (β=14.545, 0.103; P<0.05); In the elderly group, RBC and HCT were independently correlated with 25-(OH)D (β=9.939, 0.672; P<0.05) . Conclusions Vitamin D deficiency and insufficiency is prevalent in middle-aged and elderly women. Vitamin D deficiency can affect the levels of red blood cell parameters.

Key words: middle-aged and elderly women, 25-hydroxy vitamin D, anemia, red blood cell parameters

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