人体成分与骨密度的增龄性相关分析

doi:10.3969/j.issn.1003-9198.2021.10.004

摘要/Abstract

摘要： 目的分析人体成分与不同年龄段人群骨密度(BMD)的相关性。方法纳入288例在我院体检的健康人群,应用人体成分分析仪检测并记录其体脂率、体脂含量、内脏脂肪面积、去脂体质量、肌肉量等人体成分指标。采用美国HOLOGIC discovery系列骨密度仪测量上述人群的BMD。将研究对象按照年龄分为青年组(30~44岁,n=70)、中年组(45~59岁,n=105)和老年组(60~75岁,n=113),采用Pearson相关系数描述不同年龄组人体成分与BMD的关系;采用多元线性回归分析BMD的独立影响因素。结果老年组的BMD值较青、中年组降低,骨质疏松症发生率明显高于青年组,差异均有统计学意义(P<0.05)。3组人群的体质量、BMI、体脂率差异无统计学意义(P>0.05);与青年组相比,中、老年组内脏脂肪面积显著增加,老年组去脂体质量、肌肉量明显减少,差异均有统计学意义(P<0.05)。Pearson相关分析显示,BMD与3组人群的年龄呈负相关,且随着年龄增长,该相关性逐渐增强(中、青、老年组分别为r=-0.22、-0.28、-0.37,均P<0.01);中、老年组BMD与去脂体质量及肌肉量均呈正相关,且老年组的相关性更加显著(中年组:r=0.27、0.27,老年组:r=0.49、0.49,均P<0.01)。多元线性回归分析结果表明,年龄是BMD的独立危险因素,去脂体质量、肌肉量均是BMD的保护因素。结论老年人骨量减少与年龄及去脂体质量和肌肉量的增龄性改变相关。去脂体质量和肌肉量是BMD的保护因素。

关键词: 人体成分, 骨密度, 体质量指数, 去脂体质量, 肌肉质量, 增龄

Abstract: Objective To analyze the correlation between body composition and bone mineral density (BMD) among different age groups. Methods A total of 288 healthy people who underment physical examination in our hospital were enrolled and tested by body composition analyzer.The age, body mass index (BMI), body fat percentage, body fat mass, visceral fat area, lean mass and muscle mass were recorded. The value of BMD of all the populations was measured by HOLOGIC discovery system. The subjects were divided into young group (30-44 years old, n=70), middle-aged group (45-59 years old, n=105) and elderly group (60-75 years old, n=113) according to the age. Pearson correlation coefficient was used to describe the correlation between body composition and BMD. The independent factors of BMD were analyzed by multiple linear regression. Results The value of BMD in the elderly group was significantly lower than that in the young and middle-aged groups(P<0.05), and the incidence rate of osteoporosis in the elderly group was significantly higher than that in the young group (P<0.05). There were no significant differences in body mass, BMI or body fat percentage among the three groups (P>0.05). Compared with the young group, the area of visceral fat in the middle-aged and elderly groups was significantly increased, while the lean mass and muscle mass of the elderly group were significantly decreased, with statistical significant differences (P<0.05). Pearson correlation analysis showed that BMD was negatively correlated of BMD with age of the three groups. With the increase of age, the correlation of BMD with age was more significant (r=-0.22, -0.28, -0.37, all P<0.01). BMD was positively correlated with lean mass and muscle mass in the middle-aged and elderly group, especially in the elderly group (middle-aged group:r=0.27, r=0.27; elderly group: r=0.49, r=0.49, both P<0.01). Multiple linear regression analysis showed that age was an independent risk factor for BMD, while lean mass and muscle mass were protective factors for BMD. Conclusions Loss of bone mass in the elderly is associated with aging and age-related changes in lean mass and muscle mass. Lean mass and muscle mass are protective factors for BMD.

Key words: body composition, bone mineral density, body mass index, lean mass, muscle mass, aging

中图分类号:

R 589.5

操明, 阮磊, 吴晓芬, 张存泰, 杨思思. 人体成分与骨密度的增龄性相关分析[J]. 实用老年医学, 2021, 35(10): 1012-1015.

CAO Ming, RUAN Lei, WU Xiao-fen, ZHANG Cun-tai, YANG Si-si. Correlation of body composition and bone mineral density with aging[J]. Practical Geriatrics, 2021, 35(10): 1012-1015.

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