实用老年医学

实用老年医学 ›› 2010, Vol. 24 ›› Issue (1): 73-.

• 论著 • 上一篇    下一篇

抗凝治疗慢性阻塞性肺疾病急性加重疑诊肺栓塞的临床观察

  

  • 出版日期:2010-02-20 发布日期:2010-03-26

Clinical observation of anticoagulation for acute exacerbation of chronic obstructive pulmonary disease with coexisting suspected acute pulmonary embolism

  • Online:2010-02-20 Published:2010-03-26

被引次数

24

摘要：

目的探讨慢性阻塞性肺疾病急性加重(AECOPD)疑诊肺栓塞（PE）进行抗凝治疗的有效性。方法将D二聚体阳性的42例重度AECOPD患者分为血氧分压正常组（A组）和低氧血症组（B组）,并进一步随机分为抗凝（A1、B1）和非抗凝（A2、B2）2个亚组。观察A组和B组抗凝和非抗凝治疗前后的变化。结果B1组与B2组比较，临床症状、动脉血气分析、D二聚体水平等比较差异有统计学意义（P＜005），B1组优于B2组。结论具有PE高危因素，D二聚体阳性的重度AECOPD患者，应常规予以抗凝治疗。

Abstract:

ted to Medical College Nanjing University, Nanjing 210008, China
【Ａｂｓｔｒａｃｔ】　ＯｂｊｅｃｔｉｖｅTo investigate the efficacy of the anticoagulation for acute exacerbation of chronic obstructive pulmonary disease(AECOPD) with coexisting suspected acute pulmonary embolism(PE).ＭｅｔｈｏｄｓFortytwo inpatients with severe AECOPD with a positive Ddimer assay were divided into group A (a value of PaO2 was normal) and group B(hypoxia). The two groups were randomly redistributed into anticoagulation subgroups (A1 and B1) and nonanticoagulation subgroups (A2 and B2). The consequences of the management were surveyed and assessed.ＲｅｓｕｌｔｓCompared with  B2 subgroup, there were significant differences in dyspnea, PaO2,Ddimer(P＜005) in B1 subgroup.ＣｏｎｃｌｕｓｉｏｎｓAnticoagulation should immedidately be given to patients with severe AECOPD who have risk factors for venous thromboembolism or high probability for PE.