实用老年医学

实用老年医学 ›› 2010, Vol. 24 ›› Issue (1): 30-.

• 论著 • 上一篇    下一篇

美金刚对阿尔茨海默病患者血清SOD和NSE的影响

  

  1. 南京医科大学附属南京脑科医院老年神经科
  • 出版日期:2010-02-20 发布日期:2010-03-26


Effects of memantine on serum SOD and NSE in patients with Alzheimers disease

  • Online:2010-02-20 Published:2010-03-26

被引次数

16

摘要：

目的通过应用美金刚治疗阿尔茨海默病，探讨血浆超氧化物歧化酶(SOD)和神经元特异性烯醇化酶(NSE)浓度变化与认知功能改善的关系。方法符合美国精神障碍诊断与统计手册第4版诊断标准的阿尔茨海默病(AD)患者67例，随机分为美金刚治疗组和常规治疗组，另外选取对照组39例，在入组前、治疗第1月、3月及6月时，测定其SOD和NSE浓度及进行简易精神状态检查量表(MMSE)评分。结果治疗6月后，美金刚治疗组血清SOD浓度和MMSE评分明显高于常规治疗组，NSE浓度明显低于常规治疗组（P＜005）；治疗6月后，美金刚治疗组血清SOD浓度和MMSE评分明显高于治疗前，NSE浓度明显低于治疗前（P＜005）。结论应用美金刚治疗AD可以提高SOD含量，减少NSE生成，减轻氧化应激损伤，取得较好的疗效。

Abstract:

ＯｂｊｅｃｔｉｖｅTo observe the effects of memantine on serum SOD and NSE in patients with Alzheimers disease(AD).ＭｅｔｈｏｄｓSixtyseven elderly patients with AD were randomly divided into memantine treatment group and routine treatment group. Thirtynine healthy subjects were chosen as normal group. The serum concentration of SOD was measured by chemical colorimetry. The serum concentration of NSE was measured by enzymelinked immunosorbent assay (ELISA).ＲｅｓｕｌｔｓAfter 6 months of treatment, the level of serum SOD and the score of MMSE in memantine treatment group were higher than those in normal treatment group; the level of NSE in memantine treatment group was lower than that in normal treatment group. After 6 months of treatment, the serum level of SOD in memantine treatment group increased, and the serum level of NSE in memantine treatment group decreased; the score of MMSE in memantine treatment group was higher than that before treatment.ＣｏｎｃｌｕｓｉｏｎｓThe therapy of memantine could reduce oxidative stress and get better efficacy in treating AD.