老年人胃底腺型肿瘤的临床特征分析

doi:10.3969/j.issn.1003-9198.2026.07.015

Abstract

Abstract: Objective To analyze the clinical, endoscopic and pathological characteristics of fundic gland type neoplasms in the elderly. Methods A retrospective analysis was conducted on 19 patients diagnosed with fundic gland type neoplasms from January 2020 to June 2025 at Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University. Results A total of 19 patients aged 60-86 years were enrolled in this study, including 8 cases of oxyntic gland adenoma, 11 cases of gastric adenocarcinoma of the fundic gland type. All 19 cases were single gastric fundic gland-type tumors, and 8 cases were complicated with gastric diseases such as multiple gastric polyps and gastric stromal tumors. Digestive endoscopy showed that 17 cases had lesions located at the upper 1/3 of the stomach, and 2 cases had lesions located at the middle 1/3 of the stomach. Under white-light endoscopy, most of the lesions showed polypoid or submucosal tumor-like changes. The main Paris classification was type 0-Ⅱa or 0-Ⅱb. Among them, 14 cases had a reddish surface color, and 5 cases showed a faded color change. After endoscopic submucosal dissection (ESD), endoscopic mucosal resection or biopsy forceps resection, no recurrence or metastasis was found in all patients. One patient received additional surgical treatment after ESD. No recurrence or metastasis was observed postoperatively. Immunohistochemistry showed diffuse expression of mucin 6 (MUC6) and synaptophysin (Syn), sporadic expression of chromogranin A (CgA), and a low Ki-67 proliferation index. Conclusions Fundic gland type neoplasm, is a rare and special type of tumor, for which endoscopic treatment is safe and effective, and the prognosis is relatively good. However, there is currently insufficient understanding of it, and it is very easy to be missed or misdiagnosed. Therefore, it is still necessary to improve the understanding, diagnosis and treatment of fundic gland type neoplasms.

Key words: fundic gland type neoplasms, oxyntic gland adenoma, gastric adenocarcinoma of the fundic gland type, immunohistochemistry, aged

CLC Number:

R 735.2

YU Hong, A Nan, WANG Chengfan, HE Wei, WANG Xiang, YANG Qinyi. Analysis of clinical features of fundic gland type neoplasms in the elderly[J]. Practical Geriatrics, 2026, 40(7): 725-730.

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Analysis of clinical features of fundic gland type neoplasms in the elderly

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