Practical Geriatrics ›› 2026, Vol. 40 ›› Issue (7): 662-666.doi: 10.3969/j.issn.1003-9198.2026.07.004

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Advances in the diagnosis and management of liver fibrosis in the elderly

WANG Siya, YIN Shi   

  1. Department of Geriatrics, Anhui Key Laboratory of Geriatric Immunology and Nutritional Therapy, the First Affiliated Hospital of USTC, Hefei 230001, China
  • Received:2026-04-15 Published:2026-07-21
  • Contact: YIN Shi, Email:yinshi11@163.com

Abstract: A complex bidirectional regulatory relationship exists between aging and liver fibrosis. Elderly patients with liver fibrosis demonstrate distinct features in etiology, pathophysiology, comorbidity patterns, and treatment tolerance. This paper systematicly reviews current knowledge on the common causes and clinical characteristics of geriatric liver fibrosis, the mechanisms underlying the aging-fibrosis interplay, progress in diagnostic modalities, and emerging anti-fibrotic therapies. The review highlights the urgent need to refine non-invasive diagnostic approaches and to develop individualized, multifaceted anti-fibrotic management strategies tailored to the elderly population.

Key words: aged, liver fibrosis, aging

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