Abstract: Objective To explore the risk factors of early neurological deterioration (END) in the elderly patients with spontaneous intracerebral hemorrhage (SICH). Methods A retrospective analysis was conducted on the clinical data of 100 elderly patients with SICH admitted to our hospital from January 2019 to September 2022. According to the results of the National Institutes of Health Stroke Scale (NIHSS), all patients were divided into non-END group (n=60) and END group (n=40). The general information and laboratory indicators including homocysteine (Hcy) and C-reactive protein (CRP) were collected and compared between the two groups.Multivariate Logistic regression analysis was used to analyze the influencing factors of END in the elderly patients with SICH. Results The incidence rate of END in 100 patients with SICH was 40.00％ (40／100). The proportion of hypertension, hemorrhage breaking into the ventricle, hematoma volume, and the levels of CRP and Hcy in the non-END group were lower than those in the END group (P<0.05). The results of multivariate Logistic regression analysis showed that hypertension, hematoma volume, intraventricular hemorrhage, CRP and Hcy were risk factors for the occurrence of END in the elderly patients with SICH. Conclusions The occurrence of END in patients with SICH is influenced by multiple factors. When the volume of hematoma, CRP and HCY increase, attention should be paid to the occurrence of END.

Key words: spontaneous intracerebral hemorrhage, early deterioration of neurological function, homocysteine, C-reactive protein