Abstract: Objective To study the relationship of serum 25-hydroxyvitamin D[25(OH)D] level with dyslipidemia and the risk of related cardio-cerebrovascular events in the elderly hypertensive patients. Methods The clinical data of 309 elderly hypertensive patients in Wuzhou Workers' Hospital were collected and analyzed retrospectively. According to the serum 25(OH)D level, the patients were divided into deficient group (≤ 20 ng/mL, n=96), inadequate group (＞21-29 ng/mL, n=108), and adequate group (＞29 ng/mL, n=105). The serum levels of 25(OH)D, fasting plasma glucose (FPG), 2-hour postprandial blood glucose (2hPG), glycosylated hemoglobin (HbA1c), 24-hour mean systolic blood pressure (24hSBP), 24-hour mean diastolic blood pressure (24hDBP), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) were detected, and the incidence of dyslipidemia and cardio-cerebrovascular events were recorded, The correlation of 25(OH)D with dyslipidemia and the risk of cardio-cerebrovascular events were analyzed. Results The level of serum HDL-C was lower, and the levels of 24hSBP,TC,TG and LDL-C were higher in the deficient group than those in the inadequate group and the adequate group (P<0.05). The level of 25(OH)D was negatively correlated with the level of TC, TG, LDL-C, the incidence rates of dyslipidemia and cardio-cerebrovascular events (r=-0.281, -0.342, -0.189, -0.231, -0.229, all P<0.05), and positively correlated with the level of HDL-C (r=0.193,P=0.008). Conclusions The level of 25(OH)D in the elderly hypertensive patients is associated with the risk of dyslipidemia and cardio-cerebrovascular events. The patients with 25(OH)D deficiency are prone to suffering from dyslipidemia and increased cardio-cerebrovascular events risk.

Key words: hypertension, serum 25-hydroxyvitamin D, dyslipidemia, cardio-cerebrovascular events