Abstract: Objective To investigate the effects of individualized enteral nutrition under the concept of enhanced recovery after surgery(ERAS) on immune function and inflammatory cytokines in the elderly patients with craniocerebral injury. Methods A total of 94 elderly patients with craniocerebral injury were randomly divided into the observation group and the control group, with 47 patients in each group. The observation group was given individualized enteral nutrition support 48 hours after admission, and the control group was given routine enteral nutrition treatment. The levels of inflammatory factors such as interleukin 6(IL-6), IL-8, tumor necrosis factor-α(TNF-α) and T lymphocyte subsets were measured before and 14 days after treatment. The infection rate and hospitalization time were compared between the two groups. Results After 14 days of treatment, the levels of serum IL-6, IL-8 and TNF-α in the two groups were significantly decreased (P<0.05), and the immune function indexes such as CD4⁺, CD8⁺ and CD4⁺/CD8⁺ were significantly increased (P<0.05),especially in the observation group (P＜0.05 or P<0.01). The hospitalization time of the observation group was significantly shorter than that of the control group. Conclusions Under the concept of ERAS, individualized enteral nutrition can effectively improve the immune function of the elderly patients with craniocerebral injury, reduce the levels of inflammatory factors, and promote the patients' recovery.

Key words: individualized enteral nutrition, craniocerebral injury, immune function, inflammatory cytokine