Abstract: Objective To observe the effect of transanal ileus tube combined with early enteral nutrition in the treatment of the elderly patients with colorectal cancer complicated with closed loop obstruction. Methods Forty-three patients with colorectal malignant tumor complicated with intestinal obstruction admitted to the Department of General Surgery of Jiangsu Province Hospital of Traditional Chinese Medicine from January 2018 to October 2020 were selected and divided into the treatment group (n=23) and the control group (n=20). The treatment group received transanal ileus tube decompression combined with early enteral nutrition. The control group received routine treatment such as fasting and parenteral nutrition. Both groups received operation after 5-7 days. The postoperative inflammation, nutrition and immune indexes, the rate of laparoscopic surgery, the rate of anastomosis, the postoperative fever rate, the time of first deflation, the postoperative hospital stay and the total hospitalization expense were compared between the two groups. Results In the treatment group, the rate of laparoscopic surgery, the rate of anastomosis, the time of first deflation, postoperative hospitalization day, total hospitalization expense were better than those in the control group (P<0.05 or P<0.01), and there was no statistical difference in fever rate between the two groups (P>0.05). The levels of postoperative inflammatory indexes in the treatment group were lower than those in the control group (P<0.05 or P<0.01). The levels of albumin and transferrin in the treatment group were higher than those in the control group (P<0.01). CD3, CD4 and CD8 cell counts in the treatment group were higher than those in the control group (P<0.05 or P<0.01), and there was no significant difference in CD4/CD8 (P>0.05). Conclusions The method adopted in this study has a pre-rehabilitation effect on intestinal function, and can effectively improve the inflammatory, nutritional and immune status of the patients, and reduce the complications, which is conducive to the recovery of patients.

Key words: transanal ileus tube, early enteral nutrition, pre-rehabilitation of intestinal function