三阴性乳腺癌组织中FGFR1蛋白水平及Ki67表达与微血管密度的关系分析

doi:10.3969/j.issn.1003-9198.2021.08.011

Abstract

Abstract: Objective To explore the relationship of fibroblast growth factor receptor-1(FGFR1) protein level and Ki67 expression with microvessel density(MVD) in triple negative breast cancer (TNBC) tissue. Methods A total of 140 breast cancer patients diagnosed and treated in our hospital from May 2018 to March 2019 were enrolled, including 100 cases of TNBC patients(TNBC group) and 40 cases of non-TNBC patients (non-TNBC group). The expression levels of FGFR1, Ki67 and MVD in the two groups were compared, and the relationship of FGFR1 protein level and Ki67 expression with MVD in the TNBC patients with different pathological states was analyzed. Results The expression levels of FGFR1 and Ki67 in TNBC group were significantly higher than those in non-TNBC group (P<0.01). There were significance differences in the expression levels of GFR1, Ki67, MVD between the TNBC patients with different tumor size, TNM stage, lymphatic metastasis and MVD level (P＜0.05). Correlation analysis showed that the tumor size, TNM stage, lymph node metastasis and MVD level were all positively correlated with the expression levels of GFR1 and Ki67 (P＜0.05). Conclusions The expressions of FGFR1 and Ki67 in TNBC tissue are significantly correlated with MVD. In the future, FGFR1 and Ki67 can be used to analyze the disease progression.

Key words: fibroblast growth factor receptor-1, Ki67, microvessel density, triple negative breast cancer

CLC Number:

R 737.9

XU Chao, HAN Zheng-xiang, ZHOU Lei, SUN Bo. Relationship of FGFR1 protein level and Ki67 expression with microvessel density in triple negative breast cancer tissue[J]. Practical Geriatrics, 2021, 35(8): 833-836.

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Relationship of FGFR1 protein level and Ki67 expression with microvessel density in triple negative breast cancer tissue

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