Abstract:

Study on the relationship between plasma total anti-oxidant status and homocysteine (Hcy) levels in the diagnosis of Alzheimer's diseaseWANG Hao. Department of Clinical Laboratory; QU Zheng-wan, ZHU Li-na, JIANG Qi. Department of Psychiatry, Shanghai Pudong New Area Mental Health Center, Shanghai　200124, China
【Ａｂｓｔｒａｃｔ】　ＯｂｊｅｃｔｉｖｅTo study the relationship between plasma total anti-oxidant status(TAS) and homocysteine (Hcy) levels in the diagnosis of Alzheimer's disease(AD).Ｍｅｔｈｏｄｓ198 subjects were selected from outpatients of Shanghai Pudong New Area Mental Health Center and their plasma was tested for the items of TAS and Hcy levels by enzymatic methods.ＲｅｓｕｌｔｓThere were significant differences in TAS and Hcy levels between the test group and control group (both P＜0.01). ＣｏｎｃｌｕｓｉｏｎｓThere was close association between plasma TAS and Hcy levels in AD group. The hypohomocysteinemia(HHcy) may cause the lowing of plasma TAS levels, which can be one of the most important indicators in the diagnosis of AD.
【Key　ｗｏｒｄｓ】Alzheimer's disease; total antioxidant status; homocysteine