Abstract: Objective To observe the effect of intestinal microecological preparation in the elderly patients with chronic renal failure at end stage undergoing peritoneal dialysis. Methods A total of 100 elderly patients with chronic renal failure at end stage who underwent peritoneal dialysis in the hospital from January 2019 to January 2020 were selected, and they were divided into observation group and control group according to parity number method, with 50 cases in each group. The control group was treated with peritoneal dialysis and routine treatment, and the observation group was treated with peritoneal dialysis, routine treatment and intestinal microecological preparation. Both groups were treated for 2 months. The residual renal function, micro-inflammation state [C-reactive protein (CRP), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)] and oxidative stress response [malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px)] of the two groups were detected before treatment and 2 months after treatment; The incidence rate of peritonitis in the two groups was recorded during 2 months of treatment. Results After 2 months of treatment, the residual renal function of both groups was significantly lower than that before treatment, especially in the observation group (P<0. 05); The levels of CRP, hs-CRP, IL-6, TNF-α and MDA in both groups were significanty lower, while the levels of SOD and GSH-Px were significantly higher than those before treatment, especially in the observation group (P<0. 05); During the treatment, the incidence rate of peritonitis in the observation group was lower than that in the control group (P<0. 05). Conclusions The combination of intestinal microecological preparation in treatment of peritoneal dialysis in the elderly patients with chronic renal failure at end stage can improve the residual renal function, alleviate the degree of systemic micro-inflammatory response and oxidative stress, and decrease the incidence rate of peritonitis, which has a high clinical application value.

Key words: chronic renal failure, peritoneal dialysis, intestinal microecological preparation, residual renal function, micro-inflammation, oxidative stress