TRAF3IP2表达水平与老年人群冠脉钙化相关性的临床研究

doi:10.3969/j.issn.1003-9198.2026.06.012

摘要/Abstract

摘要： 目的探讨肿瘤坏死因子受体相关因子3相互作用蛋白2(TRAF3IP2)与老年人群冠状动脉钙化(CAC)的相关性。方法本研究为前瞻性研究。选取2024年10月至2025年8月在南京医科大学附属淮安第一医院接受冠脉造影的216名年龄 ≥60岁的住院患者。根据有无冠状动脉钙化分为无钙化组132例和钙化组84例。收集患者临床资料,采用ELISA法检测其血清TRAF3IP2水平,运用多因素logistic回归分析探讨TRAF3IP2与老年人群CAC之间的关系。通过绘制ROC曲线评估TRAF3IP2的预测效能。结果钙化组TRAF3IP2水平显著高于非钙化组(P<0.05)。logistic回归分析表明,TRAF3IP2与老年人群CAC的发生和严重程度均呈独立正相关(所有协变量调整后OR=1.092,P均<0.001)。ROC曲线分析显示,TRAF3IP2预测老年人群发生CAC的曲线下面积为0.664,敏感度为44.7%,特异度为89.3%。结论 TRAF3IP2与老年人群CAC存在相关性,并可能参与CAC的进展。

关键词: 肿瘤坏死因子受体3相互作用蛋白2, 老年人, 冠状动脉钙化, 炎症反应, 生物标志物, 前瞻性研究

Abstract: Objective To investigate the correlation between tumor necrosis factor receptor 3-interacting protein 2 (TRAF3IP2) and coronary artery calcification (CAC) in the elderly population. Methods This was a prospective study. A total of 216 hospitalized patients aged ≥ 60 years who underwent coronary angiography at the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University from October 2024 to August 2025 were selected. According to the presence of coronary artery calcification, the patients were divided into the non-calcification group (n=132) and the calcification group (n=84). The clinical data of the patients were collected, and enzyme-linked immunosorbent assay was used to dectect the serum level of TRAF3IP2. Multivariate logistic regression analysis was used to explore the relationship between TRAF3IP2 and CAC in the elderly population. The predictive efficacy of TRAF3IP2 for CAC was evaluated by receiver operating characteristic (ROC) curve. Results The serum level of TRAF3IP2 in the calcification group was significantly higher than that in the non-calcification group (P<0.05). Logistic regression model showed that TRAF3IP2 was independently and positively correlated with the occurrence and the severity of CAC in the elderly population (after adjustment for all covariates, OR=1.092, 1.166, all P<0.01). ROC curve analysis revealed that the area under the curve (AUC) of TRAF3IP2 for predicting CAC in the elderly population was 0.664, the diagnostic sensitivity was 44.7% and the specificity was 89.3%. Conclusions TRAF3IP2 is correlated with CAC in the elderly population, and it may be involved in the progression of CAC in the elderly population.

Key words: tumor necrosis factor receptor-associated factor 3 interacting protein 2, aged, coronary artery calcification, inflammatory response, biomarker, prospective study

中图分类号:

徐杰, 耿金, 曾杨, 张清, 王丙剑. TRAF3IP2表达水平与老年人群冠脉钙化相关性的临床研究[J]. 实用老年医学, 2026, 40(6): 602-606.

XU Jie, GENG Jin, ZENG Yang, ZHANG Qing, WANG Bingjian. Clinical study on the correlation between TRAF3IP2 expression level and coronary artery calcification in the elderly[J]. Practical Geriatrics, 2026, 40(6): 602-606.

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