甘油三酯葡萄糖指数及其衍生指数与老年冠心病病人合并心房颤动的相关性研究

doi:10.3969/j.issn.1003-9198.2025.10.015

摘要/Abstract

摘要： 目的探讨甘油三酯葡萄糖(triglyceride glucose index,TyG)指数及TyG-BMI指数与老年CHD病人合并心房颤动(AF)的关系。方法回顾性分析徐州市中心医院心血管诊疗中心2022年10月至2023年10月确诊为CHD的病人261例,根据病人住院期间是否合并AF分为CHD合并AF组(n=133)和CHD无AF组(n=128)。收集病人的临床资料及实验室检查结果,并计算TyG指数及TyG-BMI指数。通过logistic回归分析CHD病人合并AF的危险因素,采用ROC曲线评估血清TyG指数及TyG-BMI指数对CHD病人合并AF的预测价值。采用Spearman相关系数评估TyG指数及TyG-BMI指数与AF严重程度的相关性。结果 CHD合并AF组TyG指数及TyG-BMI指数明显高于CHD无AF组,差异有统计学意义(P<0.05)。多因素logistic回归分析显示,TyG指数是CHD合并AF的独立危险因素(P<0.05)。TyG指数、TyG-BMI指数预测CHD合并AF的AUC分别为0.736(95%CI:0.675~0.797)、0.621(95%CI:0.552~0.689,P<0.05)。Spearman秩相关分析显示,TyG指数及TyG-BMI指数与AF的严重程度呈正相关(r分别为0.337、0.202,均P<0.01)。结论 TyG指数是CHD病人合并AF的独立危险因素,对AF发生具有一定的预测价值,且与AF严重程度呈正相关。监测TyG指数有助于识别AF高风险病人。

关键词: 甘油三酯葡萄糖指数, 甘油三酯葡萄糖体质量指数, 老年人, 冠状动脉粥样硬化性心脏病, 心房颤动, 胰岛素抵抗, 危险因素

Abstract: Objective To investigate the correlation of triglyceride glucose index (TyG index) and its derivative indices with atrial fibrillation (AF) in the elderly patients with coronary heart disease (CHD). Methods A retrospective analysis included 261 patients with CHD admitted to Cardiovascular Department of Xuzhou Central Hospital from October 2022 to October 2023 was conducted. All patients were divided into CHD without AF group (n=128) and CHD with AF group (n=133) according to the presence of AF during hospitalization. The clinical data and laboratory results were collected, and TyG index and TyG-BMI index were subsequently calculated. Multivariate logistic regression analysis was used to analyze the risk factors for AF in CHD patients. Receiver operating characteristic (ROC) curve analysis was used to assess the predictive value of TyG index and TyG-BMI index for AF in CHD patients. Spearman correlation coefficient was used to evaluate the correlation between TyG index, TyG-BMI index and the severity of AF. Results The levels of TyG index and TyG-BMI index in CHD with AF group were significantly higher than those in CHD without AF group (P<0.05). Multivariate logistic regression analysis showed that TyG index was an independent risk factor for AF in CHD patients (P<0.05). The areas under the ROC curve of TyG index and TyG-BMI index in predicting AF in CHD patients were 0.736 (95%CI: 0.675－0.797, P<0.05), and 0.621 (95% CI: 0.552－0.689, P<0.05), respectively. Spearman rank correlation analysis showed positive correlations between both indices and the severity of AF(r=0.337 for TyG index, r=0.202 for TyG-BMI index, both P<0.01). Conclusions TyG index is an independent risk factor for AF in CHD patients, and demonstrates predictive value for the occurrence of AF. It is positively correlated with the severity of AF. Monitoring TyG index can help identify high-risk patients with AF.

Key words: triglyceride glucose index, triglyceride glucose body mass index, aged, coronary atherosclerotic heart disease, atrial fibrillation, insulin resistance, risk factor

中图分类号:

徐慧, 李振勇, 韩冰, 杜为, 路遥, 董庆山. 甘油三酯葡萄糖指数及其衍生指数与老年冠心病病人合并心房颤动的相关性研究[J]. 实用老年医学, 2025, 39(10): 1043-1047.

XU Hui, LI Zhenyong, HAN Bing, DU Wei, LU Yao, DONG Qingshan. Association of triglyceride-glucose index and its derivative indices with atrial fibrillation in elderly patients with coronary heart disease[J]. Practical Geriatrics, 2025, 39(10): 1043-1047.

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